Multiple myeloma bone lesions in skeletal remains: Report of two known cases from the 20th century CAL Milano Cemetery Skeletal Collection

Multiple myeloma (MM) is of special interest in anthropology, in particular in the differential diagnosis with metastatic carcinoma. In this paper, we present two cases of known MM and discuss the criteria for diagnosis in comparison with the literature. Two skeletons from the identified CAL Milano...

Full description

Saved in:
Bibliographic Details
Published in:International journal of osteoarchaeology 2019-01, Vol.29 (1), p.101-107
Main Authors: Biehler‐Gomez, Lucie, Giordano, Gaia, Cattaneo, Cristina
Format: Article
Language:English
Subjects:
bone metastases
bone pathology
Forensic osteology
Forensic pathology
Human remains
Multiple myeloma
neoplastic disease
paleo‐oncology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Multiple myeloma (MM) is of special interest in anthropology, in particular in the differential diagnosis with metastatic carcinoma. In this paper, we present two cases of known MM and discuss the criteria for diagnosis in comparison with the literature. Two skeletons from the identified CAL Milano Cemetery Skeletal Collection were selected for the antemortem clinical diagnosis of MM in their associated medical data. Each lesion observed during the anthropological analysis was reported and considered. Lesions were observed in both cases in the pelvis, sacrum, ribs, vertebrae, scapulae, proximal ends of femora and humeri as well as in the skull. Moreover, they presented similar morphological traits. Consequently, lesions in MM are multifocal, round, lytic, sharply demarcated, relatively uniformly small, and specifically located in highly vascularized areas of the skeleton. These results are consistent with data from the literature and strengthen the criteria for diagnosis of the condition.
ISSN:1047-482X
1099-1212
DOI:10.1002/oa.2721