The nanoencapsulation of curcuminoids extracted from Curcuma longa L. and an evaluation of their cytotoxic, enzymatic, antioxidant and anti-inflammatory activities

Curcumin, bisdemethoxycurcumin and demethoxycurcumin are the main curcuminoids present in Curcuma longa L. and are known for their bioactivity. However, their low water solubility results in poor bioavailability and therapeutic efficacy. This work aimed to investigate the in vitro modulation capacit...

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Bibliographic Details
Published in:Food & function 2019-02, Vol.10 (2), p.573-582
Main Authors: Dos Santos, Priscila Dayane Freitas, Francisco, Cristhian Rafael Lopes, Coqueiro, Aline, Leimann, Fernanda Vitória, Pinela, José, Calhelha, Ricardo C, Porto Ineu, Rafael, Ferreira, Isabel C F R, Bona, Evandro, Gonçalves, Odinei Hess
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Adenocarcinoma
Antioxidants
Aqueous solutions
Bioavailability
Biocompatibility
Biological activity
Cervix
Curcuma longa
Curcumin
Cytotoxicity
Glutathione
Glutathione transferase
Hepatocellular carcinoma
Hydrophobicity
Inflammation
Lung carcinoma
Nanoparticles
Toxicity testing
Tumor cell lines
Tumors
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Summary:Curcumin, bisdemethoxycurcumin and demethoxycurcumin are the main curcuminoids present in Curcuma longa L. and are known for their bioactivity. However, their low water solubility results in poor bioavailability and therapeutic efficacy. This work aimed to investigate the in vitro modulation capacity on the enzymes acetylcholinesterase (AChE) and glutathione S-transferase (GST), as well as the in vitro antioxidant (OxHLIA and TBARS) and anti-inflammatory activities (RAW 264.7 test) of nanoencapsulated curcuminoids. Cytotoxicity on tumor and non-tumor cell lines was also investigated. Curcuminoid nanoparticles significantly inhibited the in vitro activity of AChE (12% inhibition at 50 μM) and GST (30% inhibition at 5 μM). They presented antioxidant activity and toxic effects against breast adenocarcinoma, lung, cervical and hepatocellular carcinoma cells when dispersed in water. Encapsulated curcuminoids exhibited bioactive properties in aqueous medium (no hydrophobic solvent added), exerting antioxidant and cytotoxic effects and acting on the cholinergic and endogenous antioxidant systems.
ISSN:2042-6496
2042-650X
DOI:10.1039/c8fo02431f