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The nanoencapsulation of curcuminoids extracted from Curcuma longa L. and an evaluation of their cytotoxic, enzymatic, antioxidant and anti-inflammatory activities
Curcumin, bisdemethoxycurcumin and demethoxycurcumin are the main curcuminoids present in Curcuma longa L. and are known for their bioactivity. However, their low water solubility results in poor bioavailability and therapeutic efficacy. This work aimed to investigate the in vitro modulation capacit...
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Published in: | Food & function 2019-02, Vol.10 (2), p.573-582 |
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creator | Dos Santos, Priscila Dayane Freitas Francisco, Cristhian Rafael Lopes Coqueiro, Aline Leimann, Fernanda Vitória Pinela, José Calhelha, Ricardo C Porto Ineu, Rafael Ferreira, Isabel C F R Bona, Evandro Gonçalves, Odinei Hess |
description | Curcumin, bisdemethoxycurcumin and demethoxycurcumin are the main curcuminoids present in Curcuma longa L. and are known for their bioactivity. However, their low water solubility results in poor bioavailability and therapeutic efficacy. This work aimed to investigate the in vitro modulation capacity on the enzymes acetylcholinesterase (AChE) and glutathione S-transferase (GST), as well as the in vitro antioxidant (OxHLIA and TBARS) and anti-inflammatory activities (RAW 264.7 test) of nanoencapsulated curcuminoids. Cytotoxicity on tumor and non-tumor cell lines was also investigated. Curcuminoid nanoparticles significantly inhibited the in vitro activity of AChE (12% inhibition at 50 μM) and GST (30% inhibition at 5 μM). They presented antioxidant activity and toxic effects against breast adenocarcinoma, lung, cervical and hepatocellular carcinoma cells when dispersed in water. Encapsulated curcuminoids exhibited bioactive properties in aqueous medium (no hydrophobic solvent added), exerting antioxidant and cytotoxic effects and acting on the cholinergic and endogenous antioxidant systems. |
doi_str_mv | 10.1039/c8fo02431f |
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Encapsulated curcuminoids exhibited bioactive properties in aqueous medium (no hydrophobic solvent added), exerting antioxidant and cytotoxic effects and acting on the cholinergic and endogenous antioxidant systems.</description><subject>Acetylcholinesterase</subject><subject>Adenocarcinoma</subject><subject>Antioxidants</subject><subject>Aqueous solutions</subject><subject>Bioavailability</subject><subject>Biocompatibility</subject><subject>Biological activity</subject><subject>Cervix</subject><subject>Curcuma longa</subject><subject>Curcumin</subject><subject>Cytotoxicity</subject><subject>Glutathione</subject><subject>Glutathione transferase</subject><subject>Hepatocellular carcinoma</subject><subject>Hydrophobicity</subject><subject>Inflammation</subject><subject>Lung carcinoma</subject><subject>Nanoparticles</subject><subject>Toxicity testing</subject><subject>Tumor cell lines</subject><subject>Tumors</subject><issn>2042-6496</issn><issn>2042-650X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNo9kc9KxDAQxoMoKurFB5CAN7GaP203OcriqrDgRcFbmaaJRtpkTVLZ9XV8UePu6sAwA_Obb2A-hE4puaKEy2sljCes5NTsoENGSlbUFXnZ_etLWR-gkxjfSQ4upZBiHx1wUsuSTcQh-n5609iB89opWMSxh2S9w95gNQY1DtZ520WslymASrrDJvgBT9czwL13r4DnVxhclxPrT-jHf4X0pm3AapV88kurLrF2X6shj3MLLlNL2-W6XU62sM70MGTChxXO5-ynTVbHY7RnoI_6ZFuP0PPs9ml6X8wf7x6mN_NC8ZKmohbCSC1rzkjHKJd8ArStuQRFBWUVaAqTcsI7VknTQstIZQgR-SdcVFyRlh-h843uIviPUcfUvPsxuHyyYVSUvKJc0ExdbCgVfIxBm2YR7ABh1VDS_FrSTMXscW3JLMNnW8mxHXT3j_4ZwH8ALjCJGA</recordid><startdate>20190220</startdate><enddate>20190220</enddate><creator>Dos Santos, Priscila Dayane Freitas</creator><creator>Francisco, Cristhian Rafael Lopes</creator><creator>Coqueiro, Aline</creator><creator>Leimann, Fernanda Vitória</creator><creator>Pinela, José</creator><creator>Calhelha, Ricardo C</creator><creator>Porto Ineu, Rafael</creator><creator>Ferreira, Isabel C F R</creator><creator>Bona, Evandro</creator><creator>Gonçalves, Odinei Hess</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0001-9087-5051</orcidid><orcidid>https://orcid.org/0000-0002-9319-4566</orcidid><orcidid>https://orcid.org/0000-0001-6230-9597</orcidid><orcidid>https://orcid.org/0000-0001-8557-7527</orcidid><orcidid>https://orcid.org/0000-0002-0778-0797</orcidid><orcidid>https://orcid.org/0000-0003-4910-4882</orcidid><orcidid>https://orcid.org/0000-0002-9528-8187</orcidid><orcidid>https://orcid.org/0000-0001-7523-1637</orcidid></search><sort><creationdate>20190220</creationdate><title>The nanoencapsulation of curcuminoids extracted from Curcuma longa L. and an evaluation of their cytotoxic, enzymatic, antioxidant and anti-inflammatory activities</title><author>Dos Santos, Priscila Dayane Freitas ; Francisco, Cristhian Rafael Lopes ; Coqueiro, Aline ; Leimann, Fernanda Vitória ; Pinela, José ; Calhelha, Ricardo C ; Porto Ineu, Rafael ; Ferreira, Isabel C F R ; Bona, Evandro ; Gonçalves, Odinei Hess</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-688f9e96320d213937a1b639ac18125ae1a7473d259fbab205f0083993853c0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acetylcholinesterase</topic><topic>Adenocarcinoma</topic><topic>Antioxidants</topic><topic>Aqueous solutions</topic><topic>Bioavailability</topic><topic>Biocompatibility</topic><topic>Biological activity</topic><topic>Cervix</topic><topic>Curcuma longa</topic><topic>Curcumin</topic><topic>Cytotoxicity</topic><topic>Glutathione</topic><topic>Glutathione transferase</topic><topic>Hepatocellular carcinoma</topic><topic>Hydrophobicity</topic><topic>Inflammation</topic><topic>Lung carcinoma</topic><topic>Nanoparticles</topic><topic>Toxicity testing</topic><topic>Tumor cell lines</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dos Santos, Priscila Dayane Freitas</creatorcontrib><creatorcontrib>Francisco, Cristhian Rafael Lopes</creatorcontrib><creatorcontrib>Coqueiro, Aline</creatorcontrib><creatorcontrib>Leimann, Fernanda Vitória</creatorcontrib><creatorcontrib>Pinela, José</creatorcontrib><creatorcontrib>Calhelha, Ricardo C</creatorcontrib><creatorcontrib>Porto Ineu, Rafael</creatorcontrib><creatorcontrib>Ferreira, Isabel C F R</creatorcontrib><creatorcontrib>Bona, Evandro</creatorcontrib><creatorcontrib>Gonçalves, Odinei Hess</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Food & function</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dos Santos, Priscila Dayane Freitas</au><au>Francisco, Cristhian Rafael Lopes</au><au>Coqueiro, Aline</au><au>Leimann, Fernanda Vitória</au><au>Pinela, José</au><au>Calhelha, Ricardo C</au><au>Porto Ineu, Rafael</au><au>Ferreira, Isabel C F R</au><au>Bona, Evandro</au><au>Gonçalves, Odinei Hess</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The nanoencapsulation of curcuminoids extracted from Curcuma longa L. and an evaluation of their cytotoxic, enzymatic, antioxidant and anti-inflammatory activities</atitle><jtitle>Food & function</jtitle><addtitle>Food Funct</addtitle><date>2019-02-20</date><risdate>2019</risdate><volume>10</volume><issue>2</issue><spage>573</spage><epage>582</epage><pages>573-582</pages><issn>2042-6496</issn><eissn>2042-650X</eissn><abstract>Curcumin, bisdemethoxycurcumin and demethoxycurcumin are the main curcuminoids present in Curcuma longa L. and are known for their bioactivity. However, their low water solubility results in poor bioavailability and therapeutic efficacy. This work aimed to investigate the in vitro modulation capacity on the enzymes acetylcholinesterase (AChE) and glutathione S-transferase (GST), as well as the in vitro antioxidant (OxHLIA and TBARS) and anti-inflammatory activities (RAW 264.7 test) of nanoencapsulated curcuminoids. Cytotoxicity on tumor and non-tumor cell lines was also investigated. Curcuminoid nanoparticles significantly inhibited the in vitro activity of AChE (12% inhibition at 50 μM) and GST (30% inhibition at 5 μM). They presented antioxidant activity and toxic effects against breast adenocarcinoma, lung, cervical and hepatocellular carcinoma cells when dispersed in water. 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subjects | Acetylcholinesterase Adenocarcinoma Antioxidants Aqueous solutions Bioavailability Biocompatibility Biological activity Cervix Curcuma longa Curcumin Cytotoxicity Glutathione Glutathione transferase Hepatocellular carcinoma Hydrophobicity Inflammation Lung carcinoma Nanoparticles Toxicity testing Tumor cell lines Tumors |
title | The nanoencapsulation of curcuminoids extracted from Curcuma longa L. and an evaluation of their cytotoxic, enzymatic, antioxidant and anti-inflammatory activities |
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