Peptides of the Innate Immune System of Plants. Part I. Structure, Biological Activity, and Mechanisms of Action

A plant immune system is able to rapidly react in response to changes in environmental conditions and provides protection against stress, pathogens, and insects. In the case of infection, plants synthesize many pathogenesis-associated compounds, including various peptides. These peptides not only ha...

Full description

Saved in:
Bibliographic Details
Published in:Russian journal of bioorganic chemistry 2018-11, Vol.44 (6), p.573-585
Main Authors: Finkina, E. I., Melnikova, D. N., Bogdanov, I. V., Ovchinnikova, T. V.
Format: Article
Language:English
Subjects:
Anticancer properties
Antiinfectives and antibacterials
Antimicrobial agents
Biochemistry
Biodiversity
Biological activity
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Immune system
Insects
Life Sciences
Lipids
Organic Chemistry
Pathogenesis
Peptides
Plants (botany)
Protease inhibitors
Review Article
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A plant immune system is able to rapidly react in response to changes in environmental conditions and provides protection against stress, pathogens, and insects. In the case of infection, plants synthesize many pathogenesis-associated compounds, including various peptides. These peptides not only have the antimicrobial activity and enhance each other’s action but participate in a complex of defense strategies as well. Peptide factors of the plant’s innate immune system have a diverse structural organization and exhibit a wide spectrum of biological activities, including antimicrobial, antiviral, antitumor, insecticidal, antiinflammatory, antiproliferative, mitogenic, and analgesic. Some of them take part in binding and transfer of lipids, whereas the others exhibit the properties of ion-channel blockers or inhibitors of proteases and α-amylases but have no toxic effect on their own and mammalian cells. Some parts of plant peptides are clinically significant food or pollen allergens. All the abovementioned facts make them attractive objects for a detailed investigation and possible practical application to various aspects of human life. This review summarizes data on a diversity of structures, biological activity, and mechanisms of the antimicrobial action of the peptides of the plant’s innate immune system.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162019010060