Treatment of Nonresponders to Oral Sumatriptan With Zolmitriptan and Rizatriptan: A Comparative Open Trial

In order to study the effect of zolmitriptan and rizatriptan in oral sumatriptan nonresponders (defined as lack of response in three or more of five attacks), 56 patients were studied in an open trial in a crossover fashion. Both zolmitriptan, 5 mg, and rizatriptan, 10 mg, were effective in the majo...

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Bibliographic Details
Published in:Headache 2000-06, Vol.40 (6), p.464-465
Main Authors: Mathew, Ninan T., Kailasam, J., Gentry, Paula, Chernyshev, Oleg
Format: Article
Language:English
Subjects:
Administration, Oral
Biological and medical sciences
Cardiovascular system
Cross-Over Studies
Drug Resistance
Humans
Medical sciences
Migraine Disorders - drug therapy
nonresponders
Oxazoles - adverse effects
Oxazoles - therapeutic use
Oxazolidinones
Pharmacology. Drug treatments
Retreatment
rizatriptan
Serotonin Receptor Agonists - adverse effects
Serotonin Receptor Agonists - therapeutic use
sumatriptan
Sumatriptan - adverse effects
Sumatriptan - therapeutic use
Triazoles - adverse effects
Triazoles - therapeutic use
Tryptamines
Vasoconstrictor Agents - adverse effects
Vasoconstrictor Agents - therapeutic use
Vasodilator agents. Cerebral vasodilators
zolmitriptan
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Summary:In order to study the effect of zolmitriptan and rizatriptan in oral sumatriptan nonresponders (defined as lack of response in three or more of five attacks), 56 patients were studied in an open trial in a crossover fashion. Both zolmitriptan, 5 mg, and rizatriptan, 10 mg, were effective in the majority of sumatriptan nonresponders. The response to rizatriptan, 10 mg, appeared to be better than to zolmitriptan, 5 mg. Approximately 19% of sumatriptan nonresponders remained nonresponders to both zolmitriptan and rizatriptan.
ISSN:0017-8748
1526-4610
DOI:10.1046/j.1526-4610.2000.00069.x