In vitro and in vivo biocompatibility of polyurethanes synthesized with castor oil polyols for biomedical devices

Polyurethanes (PUs) were synthesized with polyols derived from castor oil and isophorone diisocyanate. The materials were evaluated for their mechanical properties using stress–strain curves, thermogravimetric analysis, differential scanning calorimetry, and contact angle analysis. The biological re...

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Published in:Journal of materials research 2019-02, Vol.34 (4), p.519-531
Main Authors: Uscátegui, Yomaira L., Díaz, Luis E., Valero, Manuel F.
Format: Article
Language:English
Subjects:
Antimicrobial agents
Applied and Technical Physics
Biocompatibility
Biomaterials
Biomedical materials
Castor oil
Contact angle
Contact stresses
Differential scanning calorimetry
Diisocyanates
E coli
Elasticity
Fatty acids
Inorganic Chemistry
Materials Engineering
Materials research
Materials Science
Mechanical properties
Medical equipment
Nanotechnology
Organs
Polymers
Polyols
Polyurethane resins
Protective coatings
Pseudomonas aeruginosa
Raw materials
Skin
Strain analysis
Surgical implants
Synthesis
Thermogravimetric analysis
Tissue engineering
Transplants & implants
Triglycerides
Vegetable oils
Wound healing
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description Polyurethanes (PUs) were synthesized with polyols derived from castor oil and isophorone diisocyanate. The materials were evaluated for their mechanical properties using stress–strain curves, thermogravimetric analysis, differential scanning calorimetry, and contact angle analysis. The biological response of the materials was evaluated by determining their cell viability in vitro, antimicrobial activity against Escherichia coli and Pseudomonas aeruginosa, and biological response in vivo of PUs by means of implanting them in Wistar rats. The cell proliferation on the materials was analyzed using mouse fibroblast L929, human fibroblast MRC-5, and adult human dermal fibroblast (HDFa) cells by the ISO 10993-5 method. The materials showed no toxic effects and promoted cell proliferation. Experiments performed in vivo for 30 days in mice showed that the materials neither affected the wound healing process nor caused adverse effects or severe injuries in the dorsal mid-cervical tissue or organs on histological evaluation. PUs synthesized can be used in biomedical devices.
doi_str_mv 10.1557/jmr.2018.448
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The materials were evaluated for their mechanical properties using stress–strain curves, thermogravimetric analysis, differential scanning calorimetry, and contact angle analysis. The biological response of the materials was evaluated by determining their cell viability in vitro, antimicrobial activity against Escherichia coli and Pseudomonas aeruginosa, and biological response in vivo of PUs by means of implanting them in Wistar rats. The cell proliferation on the materials was analyzed using mouse fibroblast L929, human fibroblast MRC-5, and adult human dermal fibroblast (HDFa) cells by the ISO 10993-5 method. The materials showed no toxic effects and promoted cell proliferation. Experiments performed in vivo for 30 days in mice showed that the materials neither affected the wound healing process nor caused adverse effects or severe injuries in the dorsal mid-cervical tissue or organs on histological evaluation. 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Mater. Res</addtitle><description>Polyurethanes (PUs) were synthesized with polyols derived from castor oil and isophorone diisocyanate. The materials were evaluated for their mechanical properties using stress–strain curves, thermogravimetric analysis, differential scanning calorimetry, and contact angle analysis. The biological response of the materials was evaluated by determining their cell viability in vitro, antimicrobial activity against Escherichia coli and Pseudomonas aeruginosa, and biological response in vivo of PUs by means of implanting them in Wistar rats. The cell proliferation on the materials was analyzed using mouse fibroblast L929, human fibroblast MRC-5, and adult human dermal fibroblast (HDFa) cells by the ISO 10993-5 method. The materials showed no toxic effects and promoted cell proliferation. 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subjects Antimicrobial agents
Applied and Technical Physics
Biocompatibility
Biomaterials
Biomedical materials
Castor oil
Contact angle
Contact stresses
Differential scanning calorimetry
Diisocyanates
E coli
Elasticity
Fatty acids
Inorganic Chemistry
Materials Engineering
Materials research
Materials Science
Mechanical properties
Medical equipment
Nanotechnology
Organs
Polymers
Polyols
Polyurethane resins
Protective coatings
Pseudomonas aeruginosa
Raw materials
Skin
Strain analysis
Surgical implants
Synthesis
Thermogravimetric analysis
Tissue engineering
Transplants & implants
Triglycerides
Vegetable oils
Wound healing
title In vitro and in vivo biocompatibility of polyurethanes synthesized with castor oil polyols for biomedical devices
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