Genetic bases of comorbidity between mood disorders and migraine: possible role of serotonin transporter gene

Migraine is a common neurological disease in the population and the most associated headache with mood disorder. Although the relationship between migraine and depression is well known, the reverse correlation between depression and migraine was observed but not well understood. The tight relationsh...

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Bibliographic Details
Published in:Neurological sciences 2010-06, Vol.31 (3), p.387-391
Main Authors: Marino, Elena, Fanny, Bongiorno, Lorenzi, Cristina, Pirovano, Adele, Franchini, Linda, Colombo, Cristina, Bramanti, Placido, Smeraldi, Enrico
Format: Article
Language:English
Subjects:
Adult
Age of Onset
Bipolar Disorder - epidemiology
Bipolar Disorder - genetics
Brief Communication
Comorbidity
European Continental Ancestry Group - genetics
Female
Genetic Predisposition to Disease
Humans
INDEL Mutation
Italy
Male
Medicine
Medicine & Public Health
Migraine
Migraine Disorders - epidemiology
Migraine Disorders - genetics
Migraine with Aura - epidemiology
Migraine with Aura - genetics
Migraine without Aura - epidemiology
Migraine without Aura - genetics
Mood Disorders - epidemiology
Mood Disorders - genetics
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Polymorphism, Genetic
Psychiatry
Risk Factors
Serotonin Plasma Membrane Transport Proteins - genetics
Young Adult
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Summary:Migraine is a common neurological disease in the population and the most associated headache with mood disorder. Although the relationship between migraine and depression is well known, the reverse correlation between depression and migraine was observed but not well understood. The tight relationship between the two disturbances is also suggested by the efficacy of antidepressants for migraine treatment. Starting from these observations, we can presume that both migraine and depression have overlapping biological bases. The main target of antidepressant treatments belonging to the serotonin selective reuptake inhibitors (SSRI) type is the serotonin transporter (SERT); a well-studied polymorphic variant, in the promoter region of the gene (SERTPR), has been demonstrated to influence the availability of serotonin in the synaptic cleft. So, our group studied the possible role of the SERT as a risk factor, both for migraine and mood disorders, in a sample of 96 patients affected by both pathologies.
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-009-0183-y