Ca2+-permeabIe AMPA receptors in synaptic plasticity and neuronal death

AMPA receptors mediate fast synaptic transmission at excitatory synapses in the CNS and are crucial during neuronal development, synaptic plasticity and structural remodeling. AMPA receptors lacking GluR2 subunits are permeable to Ca2+ and Zn2+ Ca2+ permeation through AMPA receptors is crucial in se...

Full description

Saved in:
Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 2007-03, Vol.30 (3), p.126
Main Authors: Liu, Siqiong June, Zukin, R Suzanne
Format: Article
Language:English
Subjects:
Apoptosis
Lymphocyte receptors
Neurological disorders
Protein synthesis
Ribonucleic acid
RNA
Sensory perception
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue 3
container_start_page 126
container_title Trends in neurosciences (Regular ed.)
container_volume 30
creator Liu, Siqiong June
Zukin, R Suzanne
description AMPA receptors mediate fast synaptic transmission at excitatory synapses in the CNS and are crucial during neuronal development, synaptic plasticity and structural remodeling. AMPA receptors lacking GluR2 subunits are permeable to Ca2+ and Zn2+ Ca2+ permeation through AMPA receptors is crucial in several forms of synaptic plasticity and cell death associated with neurological diseases and disorders. The subunit composition and Ca2+ permeability of AMPA receptors are not static, but they are dynamically remodeled in a cell- and synapse-specific manner during development and in response to neuronal activity, sensory experience and neuronal insults. Exciting new research shows that these changes arise not only because of regulated expression of the AMPA receptor subunit GluR2, but also as a consequence of RNA editing, receptor trafficking and dendritic protein synthesis. This article reviews new insights into the role of Ca2+-permeable AMPA receptors in neuronal function and survival. [PUBLICATION ABSTRACT]
format article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_218698792</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1226165711</sourcerecordid><originalsourceid>FETCH-proquest_journals_2186987923</originalsourceid><addsrcrecordid>eNqNyrsKwjAUANAgCtbHP1xcpZCkJU3HUnwNgoODW4ntFVtqEpN06N_r4Ac4neVMSMRkJmNG5W1KIsqEiDlPxJwsvO8oZalkaUQOpeLb2KJ7obqfEIrzpQCHNdpgnIdWgx-1sqGtwfbKf23DCEo3oHFwRqseGlThuSKzh-o9rn8uyWa_u5bH2DrzHtCHqjOD-3ZfcSZFLrOcJ3-lDydfPAo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218698792</pqid></control><display><type>article</type><title>Ca2+-permeabIe AMPA receptors in synaptic plasticity and neuronal death</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Liu, Siqiong June ; Zukin, R Suzanne</creator><creatorcontrib>Liu, Siqiong June ; Zukin, R Suzanne</creatorcontrib><description>AMPA receptors mediate fast synaptic transmission at excitatory synapses in the CNS and are crucial during neuronal development, synaptic plasticity and structural remodeling. AMPA receptors lacking GluR2 subunits are permeable to Ca2+ and Zn2+ Ca2+ permeation through AMPA receptors is crucial in several forms of synaptic plasticity and cell death associated with neurological diseases and disorders. The subunit composition and Ca2+ permeability of AMPA receptors are not static, but they are dynamically remodeled in a cell- and synapse-specific manner during development and in response to neuronal activity, sensory experience and neuronal insults. Exciting new research shows that these changes arise not only because of regulated expression of the AMPA receptor subunit GluR2, but also as a consequence of RNA editing, receptor trafficking and dendritic protein synthesis. This article reviews new insights into the role of Ca2+-permeable AMPA receptors in neuronal function and survival. [PUBLICATION ABSTRACT]</description><identifier>ISSN: 0166-2236</identifier><identifier>EISSN: 1878-108X</identifier><identifier>CODEN: TNSCDR</identifier><language>eng</language><publisher>Amsterdam: Elsevier Sequoia S.A</publisher><subject>Apoptosis ; Lymphocyte receptors ; Neurological disorders ; Protein synthesis ; Ribonucleic acid ; RNA ; Sensory perception</subject><ispartof>Trends in neurosciences (Regular ed.), 2007-03, Vol.30 (3), p.126</ispartof><rights>Copyright Elsevier Sequoia S.A. Mar 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Liu, Siqiong June</creatorcontrib><creatorcontrib>Zukin, R Suzanne</creatorcontrib><title>Ca2+-permeabIe AMPA receptors in synaptic plasticity and neuronal death</title><title>Trends in neurosciences (Regular ed.)</title><description>AMPA receptors mediate fast synaptic transmission at excitatory synapses in the CNS and are crucial during neuronal development, synaptic plasticity and structural remodeling. AMPA receptors lacking GluR2 subunits are permeable to Ca2+ and Zn2+ Ca2+ permeation through AMPA receptors is crucial in several forms of synaptic plasticity and cell death associated with neurological diseases and disorders. The subunit composition and Ca2+ permeability of AMPA receptors are not static, but they are dynamically remodeled in a cell- and synapse-specific manner during development and in response to neuronal activity, sensory experience and neuronal insults. Exciting new research shows that these changes arise not only because of regulated expression of the AMPA receptor subunit GluR2, but also as a consequence of RNA editing, receptor trafficking and dendritic protein synthesis. This article reviews new insights into the role of Ca2+-permeable AMPA receptors in neuronal function and survival. [PUBLICATION ABSTRACT]</description><subject>Apoptosis</subject><subject>Lymphocyte receptors</subject><subject>Neurological disorders</subject><subject>Protein synthesis</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Sensory perception</subject><issn>0166-2236</issn><issn>1878-108X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqNyrsKwjAUANAgCtbHP1xcpZCkJU3HUnwNgoODW4ntFVtqEpN06N_r4Ac4neVMSMRkJmNG5W1KIsqEiDlPxJwsvO8oZalkaUQOpeLb2KJ7obqfEIrzpQCHNdpgnIdWgx-1sqGtwfbKf23DCEo3oHFwRqseGlThuSKzh-o9rn8uyWa_u5bH2DrzHtCHqjOD-3ZfcSZFLrOcJ3-lDydfPAo</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>Liu, Siqiong June</creator><creator>Zukin, R Suzanne</creator><general>Elsevier Sequoia S.A</general><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>20070301</creationdate><title>Ca2+-permeabIe AMPA receptors in synaptic plasticity and neuronal death</title><author>Liu, Siqiong June ; Zukin, R Suzanne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_2186987923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Apoptosis</topic><topic>Lymphocyte receptors</topic><topic>Neurological disorders</topic><topic>Protein synthesis</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Sensory perception</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Siqiong June</creatorcontrib><creatorcontrib>Zukin, R Suzanne</creatorcontrib><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Trends in neurosciences (Regular ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Siqiong June</au><au>Zukin, R Suzanne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ca2+-permeabIe AMPA receptors in synaptic plasticity and neuronal death</atitle><jtitle>Trends in neurosciences (Regular ed.)</jtitle><date>2007-03-01</date><risdate>2007</risdate><volume>30</volume><issue>3</issue><spage>126</spage><pages>126-</pages><issn>0166-2236</issn><eissn>1878-108X</eissn><coden>TNSCDR</coden><abstract>AMPA receptors mediate fast synaptic transmission at excitatory synapses in the CNS and are crucial during neuronal development, synaptic plasticity and structural remodeling. AMPA receptors lacking GluR2 subunits are permeable to Ca2+ and Zn2+ Ca2+ permeation through AMPA receptors is crucial in several forms of synaptic plasticity and cell death associated with neurological diseases and disorders. The subunit composition and Ca2+ permeability of AMPA receptors are not static, but they are dynamically remodeled in a cell- and synapse-specific manner during development and in response to neuronal activity, sensory experience and neuronal insults. Exciting new research shows that these changes arise not only because of regulated expression of the AMPA receptor subunit GluR2, but also as a consequence of RNA editing, receptor trafficking and dendritic protein synthesis. This article reviews new insights into the role of Ca2+-permeable AMPA receptors in neuronal function and survival. [PUBLICATION ABSTRACT]</abstract><cop>Amsterdam</cop><pub>Elsevier Sequoia S.A</pub></addata></record>
fulltext fulltext
identifier ISSN: 0166-2236
ispartof Trends in neurosciences (Regular ed.), 2007-03, Vol.30 (3), p.126
issn 0166-2236
1878-108X
language eng
recordid cdi_proquest_journals_218698792
source ScienceDirect Freedom Collection 2022-2024
subjects Apoptosis
Lymphocyte receptors
Neurological disorders
Protein synthesis
Ribonucleic acid
RNA
Sensory perception
title Ca2+-permeabIe AMPA receptors in synaptic plasticity and neuronal death
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T15%3A38%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ca2+-permeabIe%20AMPA%20receptors%20in%20synaptic%20plasticity%20and%20neuronal%20death&rft.jtitle=Trends%20in%20neurosciences%20(Regular%20ed.)&rft.au=Liu,%20Siqiong%20June&rft.date=2007-03-01&rft.volume=30&rft.issue=3&rft.spage=126&rft.pages=126-&rft.issn=0166-2236&rft.eissn=1878-108X&rft.coden=TNSCDR&rft_id=info:doi/&rft_dat=%3Cproquest%3E1226165711%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-proquest_journals_2186987923%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=218698792&rft_id=info:pmid/&rfr_iscdi=true