NIR Emission Nanoparticles Based on FRET Composed of AIE Luminogens and NIR Dyes for Two-photon Fluorescence Imaging

Near-infrared (NIR) nanoparticles (NPs) based on fluorescence resonance energy transfer (FRET) were prepared by co-encapsulation of a red aggregation-induced emission (AIE) molecule, 2-(4-bromophenyl)-3-(4-(4-(diphenylamino)styryl)phenyl)fumaronitrile (TB), and a commercial NIR fluorescence dye, sil...

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Bibliographic Details
Published in:Chinese journal of polymer science 2019-04, Vol.37 (4), p.401-408
Main Authors: Liu, Lei-Jing, Liu, Wen, Ji, Guang, Wu, Zhi-Yuan, Xu, Bin, Qian, Jun, Tian, Wen-Jing
Format: Article
Language:English
Subjects:
Anhydrides
Biocompatibility
Brain
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Condensed Matter Physics
Contrast agents
Dyes
Emission
Energy transfer
Fluorescence
Industrial Chemistry/Chemical Engineering
Infrared imaging
Maleic anhydride
Nanoparticles
Photon absorption
Polyethylene glycol
Polymer Sciences
Polystyrene resins
Toxicity
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Summary:Near-infrared (NIR) nanoparticles (NPs) based on fluorescence resonance energy transfer (FRET) were prepared by co-encapsulation of a red aggregation-induced emission (AIE) molecule, 2-(4-bromophenyl)-3-(4-(4-(diphenylamino)styryl)phenyl)fumaronitrile (TB), and a commercial NIR fluorescence dye, silicon 2,3-naphthalocyanine bis(trihexylsilyloxide) (NIR775) with an amphiphilic polymer poly(styrene- co -maleic anhydride) (PSMA). The surface of the NPs, PSMA@TB/NIR775, was modified with poly(ethylene glycol) (PEG) to increase the in vivo biocompatibility of the NPs. The PSMA@TB/NIR775 NPs showed a strong NIR (780 nm) narrow emission and excellent two-photon absorption property. Moreover, the NPs exhibited good monodispersity, stability, and low cytotoxicity. Under the excitation of a 1040 nm femtosecond (fs) laser, the emission peaks at 680 nm of TB and 780 nm of NIR775 excited by FRET were obtained. We utilized PSMA@TB/NIR775 NPs as fluorescent contrast agents for two-photon excited NIR microscopic imaging, and good NIR imaging effect of mouse brain vasculature was obtained with the imaging depth of about 150 μm. The FRET strategy by coencapsulating AIE molecule and NIR dye will be helpful in preparing more narrow emission NIR probes for deep-tissue biological imaging.
ISSN:0256-7679
1439-6203
DOI:10.1007/s10118-019-2206-3