The long-term effect of AHSCT on MRI measures of MS evolution: a five-year follow-up study

Using MRI, we measured disease activity and brain atrophy in nine multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (AHSCT) for a mean follow up of 63 months. We show that AHSCT is associated to a longlasting suppression of inflammation and to a marked decre...

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Bibliographic Details
Published in:Multiple sclerosis 2007-09, Vol.13 (8), p.1068-1070
Main Authors: Roccatagliata, L., Rocca, MA, Valsasina, P., Bonzano, L., Sormani, MP, Saccardi, R., Mancardi, GL, Filippi, M.
Format: Article
Language:English
Subjects:
Adult
Age of Onset
Atrophy
Biological and medical sciences
Brain - pathology
Cyclophosphamide - therapeutic use
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Follow-Up Studies
Hematopoietic Stem Cell Mobilization - methods
Hematopoietic Stem Cell Transplantation
Humans
Inflammation - prevention & control
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Medical sciences
Middle Aged
Multiple Sclerosis - pathology
Multiple Sclerosis - therapy
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Nervous system
Neurology
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Transplantation, Autologous
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Summary:Using MRI, we measured disease activity and brain atrophy in nine multiple sclerosis patients treated with autologous hematopoietic stem cell transplantation (AHSCT) for a mean follow up of 63 months. We show that AHSCT is associated to a longlasting suppression of inflammation and to a marked decrease of the rate of brain atrophy after the second year following treatment. Multiple Sclerosis 2007; 13 : 1068—1070. http://msj.sagepub.com
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458507076982