Histopathological and biochemical studies on the effect of curcumin and taurine against bisphenol A toxicity in male rats

Bisphenol A (BPA) is a chemical found in environmental xenoestrogen. In the present study, olive oil, curcumin, taurine, BPA, curcumin plus BPA, and taurine plus BPA were exposed to rats for 4 weeks via gavage. Content of malondialdehyde and activities of antioxidant enzymes (GPx, GST, SOD, CAT) and...

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Bibliographic Details
Published in:Environmental science and pollution research international 2019-04, Vol.26 (12), p.12302-12310
Main Authors: Apaydin, Fatma Gökçe, Aslanturk, Ayşe, Uzunhisarcikli, Meltem, Bas, Hatice, Kalender, Suna, Kalender, Yusuf
Format: Article
Language:English
Subjects:
Antioxidants
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Bisphenol A
Cardiotoxicity
Curcumin
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental science
Enzymes
Exposure
Heart
Malondialdehyde
Oils & fats
Olive oil
Organic chemistry
Parameters
Research Article
Rodents
Taurine
Toxicity
Waste Water Technology
Water Management
Water Pollution Control
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Summary:Bisphenol A (BPA) is a chemical found in environmental xenoestrogen. In the present study, olive oil, curcumin, taurine, BPA, curcumin plus BPA, and taurine plus BPA were exposed to rats for 4 weeks via gavage. Content of malondialdehyde and activities of antioxidant enzymes (GPx, GST, SOD, CAT) and also histopathological and cytopathological changes of heart were studied. No significant changes in all studied parameters were seen between control, olive oil, curcumin, and taurine-treated groups. However, there were significant differences in levels of malondialdehyde and activities of antioxidant enzymes in BPA-exposed rats and some histo/cytopathological changes determined. In curcumin plus BPA-exposed and taurine plus BPA-exposed groups, we measured the preventive effects on some parameters but not exactly. As a result, curcumin and taurine significantly minimized BPA-induced cardiotoxicity in rats.
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-019-04578-4