Serial Measurements of Left Ventricular Systolic and Diastolic Function by Cardiac Magnetic Resonance Imaging in Patients with Early Stage Breast Cancer on Trastuzumab

Our aim was to evaluate the temporal changes in left ventricular (LV) diastolic filling in relation to other LV parameters using cardiac MRI (CMR) in patients with HER2 positive breast cancer receiving trastuzumab therapy. Fourty-one women with early stage HER2+ breast cancer underwent serial CMR (b...

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Bibliographic Details
Published in:The American journal of cardiology 2019-04, Vol.123 (7), p.1173-1179
Main Authors: Song, Lan, Brezden-Masley, Christine, Ramanan, Venkat, Ghugre, Nilesh, Barfett, Joseph J., Chan, Kelvin K.W., Haq, Rashida, Petrella, Teresa, Dhir, Vinita, Jimenez-Juan, Laura, Chacko, Binita Riya, Kotha, Vamshi, Connelly, Kim A., Yan, Andrew T.
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Immunological - adverse effects
Antineoplastic Agents, Immunological - therapeutic use
Biomarkers
Blood pressure
Breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - drug therapy
Cancer
Cancer therapies
Cardiotoxicity
Cardiovascular disease
Chemotherapy
Diastole
ErbB-2 protein
Female
Follow-Up Studies
Heart failure
Heart rate
Heart Ventricles - diagnostic imaging
Heart Ventricles - physiopathology
Humans
Immunotherapy
Magnetic resonance imaging
Magnetic Resonance Imaging, Cine - methods
Metastasis
Middle Aged
Monoclonal antibodies
Neoplasm Staging
NMR
Nuclear magnetic resonance
Parameter identification
Patients
Peptides
Prognosis
Prospective Studies
Reduction
Stroke Volume - physiology
Systole
Targeted cancer therapy
Therapy
Trastuzumab
Trastuzumab - adverse effects
Trastuzumab - therapeutic use
Ventricle
Ventricular Dysfunction, Left - chemically induced
Ventricular Dysfunction, Left - diagnosis
Ventricular Dysfunction, Left - physiopathology
Ventricular Function, Left - drug effects
Ventricular Function, Left - physiology
Ventricular Pressure - physiology
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Summary:Our aim was to evaluate the temporal changes in left ventricular (LV) diastolic filling in relation to other LV parameters using cardiac MRI (CMR) in patients with HER2 positive breast cancer receiving trastuzumab therapy. Fourty-one women with early stage HER2+ breast cancer underwent serial CMR (baseline, 6, 12, and 18 months) after initiation of trastuzumab therapy. A single, blinded observer measured LV parameters on de-identified CMRs in random order. Linear mixed models were used to investigate temporal changes. Compared to baseline, there were significant decreases in systolic function as measured by both left ventricular ejection fraction (LVEF) (p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2018.12.046