Clastogenic and Anticlastogenic Effect of the Essential Oil from Casearia sylvestris Swart

The essential oil composition obtained from the leaves of Casearia sylvestris has been investigated by GC and GC/MS. Thirty-seven compounds were identified in the oil. The major constituents of which were beta-caryophyllene (27.5%) and bicyclogermacrene (24.2%). The clastogenic and anticlastogenic e...

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Bibliographic Details
Published in:The Journal of essential oil research 2007-07, Vol.19 (4), p.376-378
Main Authors: Sousa, F.G, Schneider, N.F.Z, Mendes, C.E, Moura, N.F. de, Denardin, R.B.N, Matuo, R, Mantovani, M.S
Format: Article
Language:English
Subjects:
anticlastogenic activity
antimutagenic activity
beta-caryophyllene
bicyclogermacrene
Casearia
Casearia sylvestris
cell lines
chemical constituents of plants
clastogenic activity
essential oil composition
essential oils
ethyl methanesulfonate
Flacourtiaceae
gamma-terpinene
gel permeation chromatography
germacrene
hepatoma
leaves
mutagenesis
plant extracts
protective effect
rats
Rattus norvegicus
β-caryophyllene
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Summary:The essential oil composition obtained from the leaves of Casearia sylvestris has been investigated by GC and GC/MS. Thirty-seven compounds were identified in the oil. The major constituents of which were beta-caryophyllene (27.5%) and bicyclogermacrene (24.2%). The clastogenic and anticlastogenic effect of the oil was tested by chromosome aberration in cells of tissue hepatoma of Rattus novergicus. The three different concentrations of C. sylvestris oil showed clastogenic effects. However, in the tests of anticlastogenicity, the same three concentrations showed protective activity when associated with ethyl methanesulfonate (EMS).
ISSN:1041-2905
2163-8152
DOI:10.1080/10412905.2007.9699309