Preparation, characterization and statistical optimization of Nevirapine loaded chitosan nanoparticle for vaginal delivery

[...]stable nanoformulation was developed successfully with very good permeation of the drug across vaginal tissue that may increase the bioavailability in the target area thereby expected to increase the therapeutic effect NVP and will reduce the systemic toxicity. Nevirapine (NVP) is an excellent...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences and research 2019-02, Vol.11 (2), p.348-358
Main Authors: Rahman, Sheikh Sofiur, Ahmed, Abdul Baquee
Format: Article
Language:English
Subjects:
Antiretroviral drugs
Bioavailability
Developing countries
Disease prevention
Drug delivery systems
Efficiency
HIV
Human immunodeficiency virus
Infections
LDCs
Methods
Nanoparticles
Pandemics
Particle size
Polyvinyl alcohol
Studies
Young adults
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Summary:[...]stable nanoformulation was developed successfully with very good permeation of the drug across vaginal tissue that may increase the bioavailability in the target area thereby expected to increase the therapeutic effect NVP and will reduce the systemic toxicity. Nevirapine (NVP) is an excellent choice for the treatment of AIDS since it is a potent nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1), blocks polymerase activity after direct binding to the HIV-1 reverse transcriptase, resulting in the disruption of the enzyme's catalytic site. [...]it is the most important prescribed inhibitor of HIV-1 in the world and remains the most prescribed antiretroviral in countries with limited economic resources. The permeation data was compared with the in-vitro release data and the results showed a slight variation in drug permeation rate but which was not observed as statistically significantly (p> 0.05). [...]the study confirmed that NVP is easily permeated across the porcine vaginal mucosa which could be meeting the required therapeutics concentration for effective treatment. 6.7 Stability study It has been reported that nanoparticle formulations were prone to aggregation. [...]the physical stability of the optimized formulation was conducted in various temperature conditions. [...]stable nanoformulation was developed successfully with very good permeation of the drug across vaginal tissue that may increase the bioavailability in the target area thereby expected to increase the therapeutic effect NVP and will reduce the systemic toxicity.
ISSN:0975-1459