Assessment of Circulating Biochemical Markers in Mice Receiving Cinnamon and Glycyrrhizin Under Carbon Tetrachloride Induced Hepatic Injury

• Published in: Proceedings of the National Academy of Sciences, India. Section B: Biological sciences India. Section B: Biological sciences, 2019-03, Vol.89 (1), p.105-111
• Main Authors: Rasool, Mahmood, Malik, Arif, Saleem, Sadia, Ansari, Shakeel Ahmed, Iqbal, Javed, Asif, Muhammad, Kamal, Mohammed Amjad, Al-Qahtani, Mohammed Hussain, Karim, Sajjad
• Format: Article
• Language: English
• Subjects: Alanine; Alanine transaminase; Albinism; Alkaline phosphatase; Aspartate transaminase; Behavioral Sciences; Biochemical markers; Biomedical and Life Sciences; Body weight; Carbon tetrachloride; Catalase; Cinnamon; Dosage; Glutathione; Glycyrrhizin; Inbreeding; Inflammation; Life Sciences; Liver; Malondialdehyde; Nucleic Acid Chemistry; Oxidative stress; Plant Biochemistry; Plant extracts; Research Article; Superoxide dismutase; Transaminase
• ISSN: 0369-8211; 2250-1746
• DOI: 10.1007/s40011-017-0920-6

The study evaluated the hepatoprotective activity of plant extracts of cinnamon and glycyrrhizin in distinct dosage ways to minimize the oxidative stress induced by carbon tetrachloride (CCl 4 ) in BALB/cJ inbred albino mice. Fifteen albino mice were divided into five groups, each group containing three mice. Group A was referred as positive control while group B, C, D and E were injected intraperitoneally with 1 mL/kg body weight of CCl 4 twice a week for 1 month. Group C and D were treated orally with isolated extracts of cinnamon @50 mg/kg and glycyrrhizin @50 mg/kg respectively on daily basis for 1 month. However, group E was treated orally with combination dose of cinnamon @50 mg/kg + glycyrrhizin @50 mg/kg body weight. The increase in the levels of alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP), triglyceride (TG), malondialdehyde (MDA) and glucose were recorded in CCl 4 induced liver injury in mice while there is decrease in the levels of total protein (TP), reduced glutathione (GSH), Superoxide dismutase (SOD) and catalase (CAT) in CCL 4 intoxicated mice. Isolated therapy of plant extracts of cinnamon and glycyrrhizin decreased the levels of ALT, AST, ALP, MDA, TG and glucose whereas increase in TP, GSH, SOD and CAT was observed in plant extracts treated mice. The best restoration of all the above said parameters near to control was observed in group of mice treated with combination dose of cinnamon and glycyrrhizin @50 mg/kg. Therefore, the present study declared the antioxidative, anti-inflammatory and hepatoprotective activity of standardized extracts of cinnamon and glycyrrhizin and their potent defensive property.