Efficient one-pot synthesis of 2,3-dihydroquinazoline-4(1H)-ones promoted by FeCl3/neutral Al2O3

2,3-Dihydroquinazolin-4(1 H )-one derivatives have been synthesized via one-pot reaction of isatoic anhydride, aromatic aldehyde, and ammonium acetate catalyzed by FeCl 3 /neutral Al 2 O 3 in tert -butanol under reflux conditions. Inexpensive and easily available reagents, convenient work-up procedu...

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Bibliographic Details
Published in:Research on chemical intermediates 2019-04, Vol.45 (4), p.2327-2339
Main Authors: Wu, Suo Juan, Zhao, Zi Qiang, Gao, Jing Shuo, Chen, Bao Hua, Chen, Guo Feng
Format: Article
Language:English
Subjects:
Aluminum oxide
Ammonium acetate
Anhydrides
Butanol
Catalysis
Chemical synthesis
Chemistry
Chemistry and Materials Science
Ferric chloride
Inorganic Chemistry
Iron chlorides
Physical Chemistry
Reagents
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Summary:2,3-Dihydroquinazolin-4(1 H )-one derivatives have been synthesized via one-pot reaction of isatoic anhydride, aromatic aldehyde, and ammonium acetate catalyzed by FeCl 3 /neutral Al 2 O 3 in tert -butanol under reflux conditions. Inexpensive and easily available reagents, convenient work-up procedure, reusable catalyst, and moderate to good yield are the salient features of this protocol.
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-018-03732-w