effect of experimentally induced insulin resistance on the leptin response to hyperinsulinaemia

OBJECTIVE: Insulin is thought to be an important regulator of leptin secretion. However, increasing evidence suggests that insulin-mediated glucose uptake rather than insulin per se regulates circulating leptin concentration. Here, we hypothesised that a reduction of insulin sensitivity, ie insulin...

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Published in:International Journal of Obesity 2002-04, Vol.26 (4), p.510-516
Main Authors: Fruehwald-Schultes, B, Oltmanns, K.M, Kern, W, Born, J, Fehm, H.L, Peters, A
Format: Article
Language:English
Subjects:
Analysis. Health state
Biological and medical sciences
blood serum
Body mass index
Body weight
Epidemiology
Functional investigation of endocrine glands and genital system
General aspects
Glucose
hyperinsulinemia
Hypoglycemia
insulin
Insulin resistance
Internal medicine
Investigative techniques, diagnostic techniques (general aspects)
leptin
Medical research
Medical sciences
men
Plasma
Public health. Hygiene
Public health. Hygiene-occupational medicine
secretion
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Summary:OBJECTIVE: Insulin is thought to be an important regulator of leptin secretion. However, increasing evidence suggests that insulin-mediated glucose uptake rather than insulin per se regulates circulating leptin concentration. Here, we hypothesised that a reduction of insulin sensitivity, ie insulin resistance, will diminish the stimulatory effect of insulin on leptin secretion as a consequence of decreased insulin-mediated glucose uptake. DESIGN: Changes in serum leptin concentration during 30 hyperinsulinaemic-hypoglycaemic clamps were studied after induction of different levels of insulin resistance in normal-weight men. In 15 subjects insulin sensitivity was reduced by exposing them to a 2.5 h antecedent hypoglycaemia (3.1 mmol/l) induced by a high rate of insulin infusion (15.0 mU/min/kg) on the day before the proper experiment ('ante-hypo' condition). In the other 15 subjects no antecedent hypoglycaemia was induced ('control' condition). The proper experiment on both conditions was a 6 h stepwise hypoglycaemic clamp induced by a constant rate of insulin infusion (1.5 mU/min/kg). SUBJECTS: Experiments were carried out in 30 lean healthy subjects (age, mean±s.e.m., 26±1 y; body mass index, 23.1±0.6 kg/m2). RESULTS: As expected, glucose demand during the clamp was lower in the ante-hypo condition than in the control condition (gram of glucose infused per kilogram body weight, 1.52±0.16 vs 2.01±0.17 g/kg; P
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0801942