Enhanced Solubility and Percutaneous Permeability of Lornoxicam gel using Biosurfactant

The short term stability studies conducted for 3 months revealed that at room temperature (25oc±1oc and RH 40%) optimized formulation was stable without much variation in drug content, viscosity, pH, and in vitro drug release study. Biosurfactant have numerous uses in pharmaceuticals, for solubiliza...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2018-07, Vol.11 (7), p.2848-2854
Main Authors: Bolmal, Udaykumar B, Pramod, H J
Format: Article
Language:English
Subjects:
Permeability
Pharmaceuticals
Pharmacy
Sodium
Spectrum analysis
Studies
Surfactants
Online Access:Get full text
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Summary:The short term stability studies conducted for 3 months revealed that at room temperature (25oc±1oc and RH 40%) optimized formulation was stable without much variation in drug content, viscosity, pH, and in vitro drug release study. Biosurfactant have numerous uses in pharmaceuticals, for solubilization of lipophilic drugs in aqueous media, as components of emulsion or surfactant self-assembly vehicles for oral and transdermal drug delivery agents to improve drug absorption and as penetration enhancer, due to its very low critical micelle concentration (CMC). The final weight of gel was adjusted using phosphate buffer pH 6.8 stirred for 20 minutes and stored in airtight container at room temperature until further analysis. To know which mathematical model best fits the obtained release profile Skin irritation test: [10] Skin irritation test was performed in six male Wistar rats.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2018.00525.5