The Levels of Vitamin E in Seminal Fluids and their association with Male Infertility: Short Review

Results: Data extracted from the previous publications clarify that treatment of idiopathic infertile males with vitamin E supplementation can lead to a considerable enhancement in semen quality; however large-scale studies will be of great benefit to achieve such conclusions. Many organs and tissue...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2018-05, Vol.11 (5), p.2152-2156
Main Authors: Alta'ee, Abdulsamie H, Majeed, Hanan Abbas, Hadwan, Mahmoud H
Format: Article
Language:English
Subjects:
Animal reproduction
Antioxidants
Breast cancer
Infertility
Lipid peroxidation
Lipids
Low density lipoprotein
Males
Mutation
Oxidative stress
Sperm
Studies
Vitamin E
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Summary:Results: Data extracted from the previous publications clarify that treatment of idiopathic infertile males with vitamin E supplementation can lead to a considerable enhancement in semen quality; however large-scale studies will be of great benefit to achieve such conclusions. Many organs and tissues like adipose tissue may reveal a deficiency of vitamin E accompanied with a number of disorders such as ischemic heart disease, male infertility, breast cancer and increase the predisposing to infections 16,32, as well as the promotion of environmental and dietary stress in both animals and humans22,24,33.Animal clinical trial show low toxicity of vitamin E and no carcinogenic, mutagenic, or teratogenic effect in comparison to human clinical trials which were found many symptoms associated with vitamin E toxicity such as nausea, stupor, and loss of appetite, as well as enhancement of calcium absorption, which in turn may lead to increase deposition and precipitation of Ca in several organs like kidney and arteries21. Other studied demonstrated positive effect for the usage of high doses of vitamin E on improving fertility 28,29, whereas opposite result is obtained by another study, in which no such advantage for the usage of high doses of combination of vitamin C and E39. [...]the usage of different doses of vitamin E in these studies range from 300 mg to 600 mg making the determination of optimum dose is a matter under discussion. [...]interesting results were presented by Rolf et al.,41 study which investigates the defense mechanism of vitamin E as an antioxidant in infertile men after treating with a high dose of E vitamin (800 mg) for a period of eight weeks.
ISSN:0974-3618
0974-306X
DOI:10.5958/0974-360X.2018.00399.2