Development of PMMA-Mon-CNT bone cement with superior mechanical properties and favorable biological properties for use in bone-defect treatment

[Display omitted] •Novel PMMA-Mon bone cement containing various amounts of carbon nanotubes is prepared.•PMMA-Mon/CNTs bone cement indicated high bioactivity and cytocompatibility.•Incorporation of CNTs into PMMA-Mon increases its tensile strength.•Cells adhesion and proliferation improved after ad...

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Bibliographic Details
Published in:Materials letters 2019-04, Vol.240, p.9-12
Main Authors: Pahlevanzadeh, F., Bakhsheshi-Rad, H.R., Ismail, A.F., Aziz, M., Chen, X.B.
Format: Article
Language:English
Subjects:
Bioactivity
Biological activity
Biological properties
Bone cements
Bone surgery
Carbon nanotubes
Cement
Crack propagation
Defects
Materials science
Mechanical properties
Monticellite
PMMA bone cement
Polymethyl methacrylate
Product development
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Summary:[Display omitted] •Novel PMMA-Mon bone cement containing various amounts of carbon nanotubes is prepared.•PMMA-Mon/CNTs bone cement indicated high bioactivity and cytocompatibility.•Incorporation of CNTs into PMMA-Mon increases its tensile strength.•Cells adhesion and proliferation improved after addition of CNTs in PMMA-Mon. Treatment of bone defects requires materials or bone cement with superior mechanical properties and favorable biological properties, but this remains unachievable to date. To address this issue, the present study aimed to synthesize and characterize a novel poly(methyl methacrylate) (PMMA) bone cement containing monticellite (Mon) and carbon nanotubes (CNTs) for bone defect treatment. Considerably better mechanical properties were noted in the PMMA-Mon-CNT vs. PMMA and PMMA-Mon bone cements due to the unique resistance of CNTs to crack formation and propagation. Favorable bioactivity was also found in the bone cements containing Mon and CNTs, whereas the PMMA bone cement presented poor bioactivity. Specifically, the incorporation of Mon and CNTs into the PMMA matrix promoted the attachment of MG63 cells compared to the PMMA cement. Thus, the PMMA-Mon-CNT bone cements developed are good potential candidates for filling bone defects in orthopedic surgeries.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2018.12.049