Elevated homocysteine levels with weight loss after lap-band® surgery: higher folate and vitamin B12 levels required to maintain homocysteine level

OBJECTIVE:: To investigate homocysteine levels and their relationship with serum folate and vitamin B12 concentrations with weight loss after the Lap-Band® form of gastric restrictive surgery, with the view to minimizing risk. METHODS:: We measured levels of fasting plasma homocysteine (tHcy), folat...

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Bibliographic Details
Published in:International Journal of Obesity 2001-03, Vol.25 (2), p.219-227
Main Authors: DIXON, J. B, DIXON, M. E, O'BRIEN, P. E
Format: Article
Language:English
Subjects:
Biological and medical sciences
Dietary supplements
Gastrointestinal surgery
Homocysteine
Hospitals
Medical sciences
Metabolism
Nutrition research
Obesity
Plasma
Proteins
Risk reduction
Stomach, duodenum, intestine, rectum, anus
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Tropical medicine
Vitamin B
Weight control
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Summary:OBJECTIVE:: To investigate homocysteine levels and their relationship with serum folate and vitamin B12 concentrations with weight loss after the Lap-Band® form of gastric restrictive surgery, with the view to minimizing risk. METHODS:: We measured levels of fasting plasma homocysteine (tHcy), folate (serum and RBC) and vitamin B12 in two groups. The study group was 293 consecutive patients at 12 (n=192) or 24 (n=101) months review after surgery. The controls were 244 consecutive patients presenting for this surgery. RESULTS:: The group losing weight had higher geometric mean tHcy levels: 10.4 (95% CI, 9.8-10.8) µmol/l compared with 9.2 (95% CI, 8.9-9.7) in controls (P
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0801474