Leptin deficiency due to lipid apheresis: a possible reason for ravenous hunger and weight gain

OBJECTIVE: To investigate how extracorporal cholesterol lowering therapy affects circulating leptin levels in patients with ravenous hunger after treatment and permanent weight gain. DESIGN: A case report. SUBJECT: 51 y old caucasian male patient with moderate chronic renal failure. MEASUREMENTS: Se...

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Bibliographic Details
Published in:International Journal of Obesity 2000-02, Vol.24 (2), p.259-260
Main Authors: Leitner, G.C, Roob, J.M, Bahadori, B, Wallner, S, Wascher, T.C
Format: Article
Language:English
Subjects:
Apheresis
Biological and medical sciences
blood glucose
blood serum
Body fat
case studies
Cholesterol
diurnal variation
Diurnal variations
energy intake
Food
food intake
food records
Hunger
Internal medicine
leptin
Lipids
Low density lipoprotein
low density lipoprotein cholesterol
males
Medical sciences
Metabolic diseases
Nephrology
Obesity
pathogenesis
patients
Physiology
radioimmunoassays
renal failure
therapeutics
Weight control
weight gain
White people
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Summary:OBJECTIVE: To investigate how extracorporal cholesterol lowering therapy affects circulating leptin levels in patients with ravenous hunger after treatment and permanent weight gain. DESIGN: A case report. SUBJECT: 51 y old caucasian male patient with moderate chronic renal failure. MEASUREMENTS: Serum Leptin concentration (RIA, Linco Research Inc, St. Louis, MO, USA), total cholesterol, low density lipoprotein cholesterol, blood glucose levels, calorie intake by food records. RESULTS: During treatment total cholesterol was reduced by 50%. Serum Leptin levels showed a 42% reduction at the end of treatment, that by far exceeds the physiological diurnal variation. Calorie intake was significantly increased on days of treatment. CONCLUSION: We conclude that this artificial reduction in circulating leptin plays an important role in the pathogenesis of ravenous hunger and weight gain under extracorporal cholesterol lowering therapy in this case.
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0801160