Measurement of abdominal fat by CT compared to waist circumference and BMI in explaining the presence of coronary calcium

OBJECTIVE: To evaluate the association between standard and computed tomography (CT)-based measures of obesity and subclinical atherosclerosis, defined as coronary artery calcium (CAC) by Electron Beam Computed Tomography (EBCT). DESIGN: Cross-sectional, observational study of anthropometric and CT...

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Bibliographic Details
Published in:International Journal of Obesity 2004-12, Vol.28 (12), p.1594-1599
Main Authors: Snell-Bergeon, J K, Hokanson, J E, Kinney, G L, Dabelea, D, Ehrlich, J, Eckel, R H, Ogden, L, Rewers, M
Format: Article
Language:English
Subjects:
Abdomen
Asymptomatic
Atherosclerosis
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Biometrics
Blood and lymphatic vessels
Body fat
Body mass index
Calcium
Cardiology. Vascular system
Cardiovascular disease
Care and treatment
Computed tomography
Coronary heart disease
Coronary vessels
CT imaging
Diabetes
Diagnosis
Disease prevention
Epidemiology
Health aspects
Health Promotion and Disease Prevention
Health risks
Health sciences
Heart
Internal Medicine
Measurement
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Obesity
Observational studies
Overweight
Preventive medicine
Public Health
Risk factors
Tomography
Vein & artery diseases
Vertebrae
Womens health
Young adults
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Summary:OBJECTIVE: To evaluate the association between standard and computed tomography (CT)-based measures of obesity and subclinical atherosclerosis, defined as coronary artery calcium (CAC) by Electron Beam Computed Tomography (EBCT). DESIGN: Cross-sectional, observational study of anthropometric and CT obesity measures and presence of CAC. SUBJECTS: Participants were 383 men and 379 women, aged 20–58 y and asymptomatic for coronary artery disease (CAD). MEASUREMENTS: Intra-abdominal fat (IAF) and subcutaneous fat (SQF) were measured at the level of lumbar 2–3 and 4–5 spaces, using EBCT. Body mass index (BMI) was calculated from height and weight, and minimum waist circumference and maximum hip circumference were measured. CAC was measured by EBCT. RESULTS: In both men and women, BMI, waist circumference, IAF, and SQF were significantly related to CAC. However, BMI or waist circumference explained variation in the presence of CAC as well as IAF or SQF, univariately and after adjustment for additional cardiovascular risk factors. CONCLUSION: CT-based obesity exposure measures are not superior to BMI or waist circumference in association studies of subclinical CAD.
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0802796