Obesity is associated with decreasing levels of the circulating soluble leptin receptor in humans

OBJECTIVE: Leptin plays a major role in the regulation of body weight. It circulates in both free and bound form. One of the leptin receptor isoforms exists in a circulating soluble form that can bind leptin. In the present study, we measured the soluble leptin receptor (SLR) levels in lean and obes...

Full description

Saved in:
Bibliographic Details
Published in:International Journal of Obesity 2002-04, Vol.26 (4), p.496-503
Main Authors: Ogier, V, Ziegler, O, Méjean, L, Nicolas, J.P, Stricker-Krongrad, A
Format: Article
Language:English
Subjects:
adiposity
Biological and medical sciences
Body fat
Body mass index
Body weight
Cytokines
dual-energy X-ray absorptiometry
enzyme-linked immunosorbent assay
Enzymes
Functional investigation of endocrine glands and genital system
gel chromatography
gender
Gender differences
humans
Investigative techniques, diagnostic techniques (general aspects)
leptin
leptin receptors
low calorie diet
Medical sciences
men
Metabolic diseases
Metabolism
Nutrition research
Obesity
Overweight
Plasma
Proteins
radioimmunoassays
weight loss
women
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:OBJECTIVE: Leptin plays a major role in the regulation of body weight. It circulates in both free and bound form. One of the leptin receptor isoforms exists in a circulating soluble form that can bind leptin. In the present study, we measured the soluble leptin receptor (SLR) levels in lean and obese humans. We investigated the relationship between plasma SLR levels, plasma leptin levels and the degree of obesity. We also examined whether SLR concentrations could be modulated by fat mass loss induced by a 3 month weight-reducing diet. SUBJECTS: A total of 112 obese (age 18-50 y; body mass index (BMI) 30-44 kg/m2; 23 men and 89 women), 38 overweight (age 19-48 y; BMI 25-29 kg/m2; 10 men and 28 women) and 63 lean (age 18-50 y; BMI 17-24 kg/m2; 16 men and 47 women) humans. MEASUREMENTS: A direct double monoclonal sandwich enzyme-linked immunosorbent assay (ELISA) was used for the quantitative measurement of the soluble human leptin receptor. Leptin was measured by radioimmunoassay (RIA). Body composition was assessed by biphotonic absorptiometry DEXA (dual energy X-ray absorptiometry). RESULTS: We observed that the SLR is present in human plasma (range 10-100 ng/ml). SLR levels were lower in obese and overweight than lean subjects (28.7±8.8, 40.2±14.9, 51.2±12.5 ng/ml, respectively) and were inversely correlated to leptin and percentage of body fat (r=-0.74 and r=-0.76; respectively; P
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0801951