The effects of the selective serotonin reuptake-inhibitor fluvoxamine on body weight in Zucker rats are mediated by corticotropin-releasing hormone

Brain serotonin plays a crucial role in the regulation of food intake and body weight homeostasis. Previous data suggest an interaction with corticotropin-releasing hormone (CRH). To further examine the interaction between these neurotransmitters, the selective serotonin reuptake-inhibitor (SSRI) fl...

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Bibliographic Details
Published in:International Journal of Obesity 2001-10, Vol.25 (10), p.1566-1569
Main Authors: WIECZOREK, I, SCHULZ, C, JARRY, H, LEHNERT, H
Format: Article
Language:English
Subjects:
Animal models
Animals
Biological and medical sciences
Body weight
Endocrinology
Food
General and cellular metabolism. Vitamins
Homeostasis
Insulin
Medical sciences
Metabolism
Peptides
Pharmacology. Drug treatments
Serotonin
Surgery
Weight control
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Summary:Brain serotonin plays a crucial role in the regulation of food intake and body weight homeostasis. Previous data suggest an interaction with corticotropin-releasing hormone (CRH). To further examine the interaction between these neurotransmitters, the selective serotonin reuptake-inhibitor (SSRI) fluvoxamine was given intraperitoneally in fa/fa Zucker rats with and without the CRH-receptor-antagonist α-helical CRH administered intracerebroventriculary (i.c.v.). The saline treated animals gained weight. Fluvoxamine led to a significant weight loss while not affecting food intake. Furthermore, insulin levels in this animal model were reduced following fluvoxamine administration. These effects were antagonized by α-helical CRH and are thus most likely mediated via CRH or CRH-like peptides.INTERNATIONAL JOURNAL OF OBESITY: (2001) 25, 1566-1569
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0801729