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Enhanced glucose uptake into adipose tissue induced by early growth restriction augments excursions in plasma leptin response evoked by changes in insulin status
OBJECTIVE:: The study used a rat model of moderate protein restriction exclusively during fetal and early neonatal life, which has been established to cause intrauterine early growth retardation, to investigate possible association between adipocyte glucose utilisation and leptin secretion in vivo....
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Published in: | International Journal of Obesity 2001-12, Vol.25 (12), p.1775-1781 |
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description | OBJECTIVE:: The study used a rat model of moderate protein restriction exclusively during fetal and early neonatal life, which has been established to cause intrauterine early growth retardation, to investigate possible association between adipocyte glucose utilisation and leptin secretion in vivo. DESIGN:: These rats, termed early protein restricted, were transferred to a diet containing the standard amount of protein at weaning and remained on this diet til adulthood, at which time adipocyte glucose utilisation and leptin secretion was compared with that of age-matched controls. Insulin status was modulated by acute (2 h) insulin infusion at a constant rate (4.2 mU/min per kg) to elevate insulin to the high physiological range. Euglycaemia was maintained by variable glucose infusion. MEASUREMENTS:: Glucose utilisation was measured in vivo in conscious unrestrained rats using 2-deoxy[1-3 H] glucose. Leptin concentrations (measured by radioimmunoassay) and whole-body glucose kinetics (measured using [3-3 H] glucose) were studied in the postabsorptive state and after acute insulin stimulation. RESULTS:: Adipose-tissue glucose utilisation rates in vivo tended to be higher in the post-absorptive state and were consistently 1.8-3.0-fold higher after insulin stimulation in the early-protein-restricted group compared with the control group. Both the absolute increase in leptin concentration elicited by hyperinsulinaemia and the magnitude of the effect of insulin to elevate plasma leptin levels were greater in the early-protein-restricted group compared with the control group (by 2.2-fold and 1.6-fold, respectively). The effect of insulin to stimulate Rd was much greater in the early-protein-restricted group (4.1-fold) than in the control group (2.2-fold) and the absolute increase in Rd elicited by insulin was 43% higher in the early-protein-restricted group than in the control group. CONCLUSIONS:: It is concluded that poor early growth enhances the acute leptin response to changes in insulin status through programmed changes in adipocyte glucose handling. INTERNATIONAL JOURNAL OF OBESITY: (2001) 25, 1775-1781 |
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J</creator><creatorcontrib>HOLNESS, M. J</creatorcontrib><description>OBJECTIVE:: The study used a rat model of moderate protein restriction exclusively during fetal and early neonatal life, which has been established to cause intrauterine early growth retardation, to investigate possible association between adipocyte glucose utilisation and leptin secretion in vivo. DESIGN:: These rats, termed early protein restricted, were transferred to a diet containing the standard amount of protein at weaning and remained on this diet til adulthood, at which time adipocyte glucose utilisation and leptin secretion was compared with that of age-matched controls. Insulin status was modulated by acute (2 h) insulin infusion at a constant rate (4.2 mU/min per kg) to elevate insulin to the high physiological range. Euglycaemia was maintained by variable glucose infusion. MEASUREMENTS:: Glucose utilisation was measured in vivo in conscious unrestrained rats using 2-deoxy[1-3 H] glucose. Leptin concentrations (measured by radioimmunoassay) and whole-body glucose kinetics (measured using [3-3 H] glucose) were studied in the postabsorptive state and after acute insulin stimulation. RESULTS:: Adipose-tissue glucose utilisation rates in vivo tended to be higher in the post-absorptive state and were consistently 1.8-3.0-fold higher after insulin stimulation in the early-protein-restricted group compared with the control group. Both the absolute increase in leptin concentration elicited by hyperinsulinaemia and the magnitude of the effect of insulin to elevate plasma leptin levels were greater in the early-protein-restricted group compared with the control group (by 2.2-fold and 1.6-fold, respectively). The effect of insulin to stimulate Rd was much greater in the early-protein-restricted group (4.1-fold) than in the control group (2.2-fold) and the absolute increase in Rd elicited by insulin was 43% higher in the early-protein-restricted group than in the control group. CONCLUSIONS:: It is concluded that poor early growth enhances the acute leptin response to changes in insulin status through programmed changes in adipocyte glucose handling. INTERNATIONAL JOURNAL OF OBESITY: (2001) 25, 1775-1781</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0801836</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing</publisher><subject>Adipocytes ; Adipose tissue ; Biological and medical sciences ; Body fat ; Carbohydrates ; Diabetes ; Diet ; Dietary restrictions ; Glucose ; Insulin ; Insulin resistance ; Medical sciences ; Metabolism ; Nutrition research ; Obesity ; Plasma ; Pregnancy ; Proteins</subject><ispartof>International Journal of Obesity, 2001-12, Vol.25 (12), p.1775-1781</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Dec 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-d81127ec793c67768dc9648026b1d87d2dcbc14df275ce37dad02f01bcbec6dc3</citedby><cites>FETCH-LOGICAL-c317t-d81127ec793c67768dc9648026b1d87d2dcbc14df275ce37dad02f01bcbec6dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14160126$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>HOLNESS, M. J</creatorcontrib><title>Enhanced glucose uptake into adipose tissue induced by early growth restriction augments excursions in plasma leptin response evoked by changes in insulin status</title><title>International Journal of Obesity</title><description>OBJECTIVE:: The study used a rat model of moderate protein restriction exclusively during fetal and early neonatal life, which has been established to cause intrauterine early growth retardation, to investigate possible association between adipocyte glucose utilisation and leptin secretion in vivo. DESIGN:: These rats, termed early protein restricted, were transferred to a diet containing the standard amount of protein at weaning and remained on this diet til adulthood, at which time adipocyte glucose utilisation and leptin secretion was compared with that of age-matched controls. Insulin status was modulated by acute (2 h) insulin infusion at a constant rate (4.2 mU/min per kg) to elevate insulin to the high physiological range. Euglycaemia was maintained by variable glucose infusion. MEASUREMENTS:: Glucose utilisation was measured in vivo in conscious unrestrained rats using 2-deoxy[1-3 H] glucose. Leptin concentrations (measured by radioimmunoassay) and whole-body glucose kinetics (measured using [3-3 H] glucose) were studied in the postabsorptive state and after acute insulin stimulation. RESULTS:: Adipose-tissue glucose utilisation rates in vivo tended to be higher in the post-absorptive state and were consistently 1.8-3.0-fold higher after insulin stimulation in the early-protein-restricted group compared with the control group. Both the absolute increase in leptin concentration elicited by hyperinsulinaemia and the magnitude of the effect of insulin to elevate plasma leptin levels were greater in the early-protein-restricted group compared with the control group (by 2.2-fold and 1.6-fold, respectively). The effect of insulin to stimulate Rd was much greater in the early-protein-restricted group (4.1-fold) than in the control group (2.2-fold) and the absolute increase in Rd elicited by insulin was 43% higher in the early-protein-restricted group than in the control group. CONCLUSIONS:: It is concluded that poor early growth enhances the acute leptin response to changes in insulin status through programmed changes in adipocyte glucose handling. INTERNATIONAL JOURNAL OF OBESITY: (2001) 25, 1775-1781</description><subject>Adipocytes</subject><subject>Adipose tissue</subject><subject>Biological and medical sciences</subject><subject>Body fat</subject><subject>Carbohydrates</subject><subject>Diabetes</subject><subject>Diet</subject><subject>Dietary restrictions</subject><subject>Glucose</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Nutrition research</subject><subject>Obesity</subject><subject>Plasma</subject><subject>Pregnancy</subject><subject>Proteins</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNpFUcGO2yAURNWutNlsr3tGlfboFLANzrGKdreVIvXSni38wAmOY1webJvP6Z-WNJH2NHrDzABvCHnkbMVZ2XzGYeUGv2IN400pP5AFr5Qs6mqtbsiClUwVrJb1HblHHBhjdc3Egvx9nvZ6Amvobkzg0dI0R32w1E3RU23cfOaiQ0xnzqSztDtRq8N4orvgf8c9DRZjcBCdn6hOu6OdIlL7B1LATGH20XnUeNR0tHPMUzbM-cBS--YPl0DIz9jZ_1o3YRozYtQx4QO57fWI9uMVl-Tny_OPzddi-_312-bLtoCSq1iYhnOhLKh1CVIp2RhYy6phQnbcNMoIAx3wyvRC1WBLZbRhome8g86CNFAuyadL7hz8r5R_1A4-hSlf2Qq-FrLhkmXR6iKC4BGD7ds5uKMOp5az9txCi0ObW2ivLWTD0zVVI-ixD3nZDt9dVU7lQpb_ANEpjgA</recordid><startdate>20011201</startdate><enddate>20011201</enddate><creator>HOLNESS, M. 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J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-d81127ec793c67768dc9648026b1d87d2dcbc14df275ce37dad02f01bcbec6dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adipocytes</topic><topic>Adipose tissue</topic><topic>Biological and medical sciences</topic><topic>Body fat</topic><topic>Carbohydrates</topic><topic>Diabetes</topic><topic>Diet</topic><topic>Dietary restrictions</topic><topic>Glucose</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Nutrition research</topic><topic>Obesity</topic><topic>Plasma</topic><topic>Pregnancy</topic><topic>Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HOLNESS, M. J</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HOLNESS, M. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced glucose uptake into adipose tissue induced by early growth restriction augments excursions in plasma leptin response evoked by changes in insulin status</atitle><jtitle>International Journal of Obesity</jtitle><date>2001-12-01</date><risdate>2001</risdate><volume>25</volume><issue>12</issue><spage>1775</spage><epage>1781</epage><pages>1775-1781</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>OBJECTIVE:: The study used a rat model of moderate protein restriction exclusively during fetal and early neonatal life, which has been established to cause intrauterine early growth retardation, to investigate possible association between adipocyte glucose utilisation and leptin secretion in vivo. DESIGN:: These rats, termed early protein restricted, were transferred to a diet containing the standard amount of protein at weaning and remained on this diet til adulthood, at which time adipocyte glucose utilisation and leptin secretion was compared with that of age-matched controls. Insulin status was modulated by acute (2 h) insulin infusion at a constant rate (4.2 mU/min per kg) to elevate insulin to the high physiological range. Euglycaemia was maintained by variable glucose infusion. MEASUREMENTS:: Glucose utilisation was measured in vivo in conscious unrestrained rats using 2-deoxy[1-3 H] glucose. Leptin concentrations (measured by radioimmunoassay) and whole-body glucose kinetics (measured using [3-3 H] glucose) were studied in the postabsorptive state and after acute insulin stimulation. RESULTS:: Adipose-tissue glucose utilisation rates in vivo tended to be higher in the post-absorptive state and were consistently 1.8-3.0-fold higher after insulin stimulation in the early-protein-restricted group compared with the control group. Both the absolute increase in leptin concentration elicited by hyperinsulinaemia and the magnitude of the effect of insulin to elevate plasma leptin levels were greater in the early-protein-restricted group compared with the control group (by 2.2-fold and 1.6-fold, respectively). The effect of insulin to stimulate Rd was much greater in the early-protein-restricted group (4.1-fold) than in the control group (2.2-fold) and the absolute increase in Rd elicited by insulin was 43% higher in the early-protein-restricted group than in the control group. CONCLUSIONS:: It is concluded that poor early growth enhances the acute leptin response to changes in insulin status through programmed changes in adipocyte glucose handling. INTERNATIONAL JOURNAL OF OBESITY: (2001) 25, 1775-1781</abstract><cop>Basingstoke</cop><pub>Nature Publishing</pub><doi>10.1038/sj.ijo.0801836</doi><tpages>7</tpages></addata></record> |
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subjects | Adipocytes Adipose tissue Biological and medical sciences Body fat Carbohydrates Diabetes Diet Dietary restrictions Glucose Insulin Insulin resistance Medical sciences Metabolism Nutrition research Obesity Plasma Pregnancy Proteins |
title | Enhanced glucose uptake into adipose tissue induced by early growth restriction augments excursions in plasma leptin response evoked by changes in insulin status |
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