Impaired fasting glycaemia in middle-aged women: a prospective study

• Published in: International Journal of Obesity 2001-05, Vol.25 (5), p.646-651
• Main Authors: BALL, M, DUDLEY, E. C, GARAMSZEGI, C. V, WAHLQVIST, M. L, DENNERSTEIN, L, GUTHRIE, J. R, BURGER, H. G
• Format: Article
• Language: English
• Subjects: Analysis. Health state; Androgens; Automation; Biological and medical sciences; Blood pressure; Body mass index; Cardiovascular disease; Cholesterol; Epidemiology; General aspects; Glucose; Insulin; Insulin resistance; Interviews; Longitudinal studies; Medical sciences; Menopause; Menstruation; Metabolic disorders; Middle age; Obesity; Plasma; Public health. Hygiene; Public health. Hygiene-occupational medicine; Tropical medicine; Womens health
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/sj.ijo.0801569

OBJECTIVES:: To investigate: (i) the incidence of impaired fasting glycaemia (IFG) developed over 5 y in a population-based sample of Australian-born women; (ii) prospectively the factors which are associated with the development of IFG; (iii) the association of the menopausal transition with the onset of IFG and an increase in serum insulin concentrations. DESIGN AND METHODS:: A total of 265 women (110 pre-, 138 peri-, 17 postmenopausal) participants in the longitudinal phase of the Melbourne Women's Midlife Health Project, aged 46-57 and with normal fasting plasma glucose concentrations at the time of the initial measure, were interviewed, had physical measurements and blood taken annually over a 5 y follow-up period. RESULTS:: During the study period 43 women (16%) recorded a fasting glucose concentration of ≥6.1 mmol/l (IFG). Women who recorded IFG prospectively had, at the time of the initial measure when fasting glucose concentrations were normal: higher body mass index (BMI), trunk skinfold thicknesses, waist and hip circumferences (P