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Effect of low-dose metoprolol in combination with sibutramine therapy in normotensive obese patients: a randomized controlled study
OBJECTIVE: Sibutramine is an effective appetite suppresser agent, but treatment is often complicated with side effects, including palpitations and hypertension. In this study, we aimed to assess the effect of low-dose cardio-selective beta blocker combination with sibutramine treatment. METHODS: In...
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| Published in: | International Journal of Obesity 2004-03, Vol.28 (3), p.378-383 |
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| cites | cdi_FETCH-LOGICAL-c489t-b94361ba986636bf6287f53aafa5af9f1ec522cc1cd5d97a3e8c74ad559941293 |
| container_end_page | 383 |
| container_issue | 3 |
| container_start_page | 378 |
| container_title | International Journal of Obesity |
| container_volume | 28 |
| creator | Ersoz, H O Ukinc, K Baykan, M Erem, C Durmus, I Hacihasanoglu, A Telatar, M |
| description | OBJECTIVE:
Sibutramine is an effective appetite suppresser agent, but treatment is often complicated with side effects, including palpitations and hypertension. In this study, we aimed to assess the effect of low-dose cardio-selective beta blocker combination with sibutramine treatment.
METHODS:
In total, 57 obese subjects were enrolled in the study and separated into two groups in order to receive sibutramine 10 mg/day plus placebo (group P) or sibutramine 10 mg/day plus metoprolol 25 mg/day (group M). Patients were evaluated in the beginning and at the end of the third month with anthropometric measurements, biochemical analysis, peripheral insulin resistance, and ambulatory 24 h blood pressure monitoring. Side effects were evaluated with a visual analog scale.
RESULTS:
During the study period, the drop-out rate was significantly higher in group P compared with group M (55 and 21%, respectively,
P
=0.014). Palpitations and headache were prominent symptoms in group P. Diastolic blood pressure (78.6±11.6 and 70.6±4.8 mmHg, respectively,
P
=0.013) and mean heart rate (84.3±6.1 and 75.8±8.4 beats/min, respectively,
P
=0.003) were significantly higher in group P compared with group M at the end of the third month. Weight loss was similar between the two groups (100.9±11.5 to 91.8±12.8 kg for group P,
P |
| doi_str_mv | 10.1038/sj.ijo.0802574 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_219278175</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A188448993</galeid><sourcerecordid>A188448993</sourcerecordid><originalsourceid>FETCH-LOGICAL-c489t-b94361ba986636bf6287f53aafa5af9f1ec522cc1cd5d97a3e8c74ad559941293</originalsourceid><addsrcrecordid>eNp1kc-P1CAUx4nRxHH16s2EmOits9CWAt42m_VHsokXPTeUPnZoWhiBuhmv_uO-yYyuHgwHCO_7_fAeX0JecrblrFGXedr6KW6ZYrWQ7SOy4a3sKtFq-ZhsWMNkxUQnnpJnOU-MMSFYvSE_b5wDW2h0dI731Rgz0AVK3Kc4x5n6QG1cBh9M8THQe192NPthLcksPgAtO0hmfzjqQkxLLBCy_w40DoCgPboglPyOGppMGOPif8CIxFAQP-Mxl3U8PCdPnJkzvDjvF-Tr-5sv1x-r288fPl1f3Va2VbpUg26bjg9Gq65rusF1tZJONMY4I4zTjoMVdW0tt6MYtTQNKCtbMwqhdctr3VyQ1ycuDvdthVz6Ka4p4JN9zXUtFZcCRduT6M7M0PvgIs5qcY2weOwcnMf7K65Ui13pBg1v_zLswMxll-O8Hj8s_ys8k22KOSdw_T75xaRDz1l_TLDPU48J9ucE0fDm3K_J1swOv9D6_OASEgNlR_DlSZexFO4gPcz1X_KrkwNzXRP8Qf6u_wJa4Lha</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219278175</pqid></control><display><type>article</type><title>Effect of low-dose metoprolol in combination with sibutramine therapy in normotensive obese patients: a randomized controlled study</title><source>Nature</source><creator>Ersoz, H O ; Ukinc, K ; Baykan, M ; Erem, C ; Durmus, I ; Hacihasanoglu, A ; Telatar, M</creator><creatorcontrib>Ersoz, H O ; Ukinc, K ; Baykan, M ; Erem, C ; Durmus, I ; Hacihasanoglu, A ; Telatar, M</creatorcontrib><description>OBJECTIVE:
Sibutramine is an effective appetite suppresser agent, but treatment is often complicated with side effects, including palpitations and hypertension. In this study, we aimed to assess the effect of low-dose cardio-selective beta blocker combination with sibutramine treatment.
METHODS:
In total, 57 obese subjects were enrolled in the study and separated into two groups in order to receive sibutramine 10 mg/day plus placebo (group P) or sibutramine 10 mg/day plus metoprolol 25 mg/day (group M). Patients were evaluated in the beginning and at the end of the third month with anthropometric measurements, biochemical analysis, peripheral insulin resistance, and ambulatory 24 h blood pressure monitoring. Side effects were evaluated with a visual analog scale.
RESULTS:
During the study period, the drop-out rate was significantly higher in group P compared with group M (55 and 21%, respectively,
P
=0.014). Palpitations and headache were prominent symptoms in group P. Diastolic blood pressure (78.6±11.6 and 70.6±4.8 mmHg, respectively,
P
=0.013) and mean heart rate (84.3±6.1 and 75.8±8.4 beats/min, respectively,
P
=0.003) were significantly higher in group P compared with group M at the end of the third month. Weight loss was similar between the two groups (100.9±11.5 to 91.8±12.8 kg for group P,
P
<0.0001 and 97.9±13.2 to 88.9±13.8 kg for group M,
P
<0.0001). We did not find any deleterious effect of metoprolol on metabolic parameters.
CONCLUSION:
Addition of low-dose metoprolol to sibutramine therapy increased patient compliance to the treatment, and decreased the frequency and severity of side effects including hypertension and palpitations, without decreasing the drug efficacy or causing significant deleterious changes in metabolic parameters.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0802574</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Arterial hypertension. Arterial hypotension ; Biochemical analysis ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood pressure ; Body mass index ; Cardiology. Vascular system ; Cardiovascular disease ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Coronary vessels ; Drug dosages ; Epidemiology ; General and cellular metabolism. Vitamins ; Health Promotion and Disease Prevention ; Heart rate ; Hypertension ; Insulin resistance ; Internal Medicine ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolism ; Obesity ; Patients ; Pharmacology. Drug treatments ; Public Health ; Side effects ; Vein & artery diseases ; Weight control</subject><ispartof>International Journal of Obesity, 2004-03, Vol.28 (3), p.378-383</ispartof><rights>Springer Nature Limited 2004</rights><rights>2004 INIST-CNRS</rights><rights>COPYRIGHT 2004 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-b94361ba986636bf6287f53aafa5af9f1ec522cc1cd5d97a3e8c74ad559941293</citedby><cites>FETCH-LOGICAL-c489t-b94361ba986636bf6287f53aafa5af9f1ec522cc1cd5d97a3e8c74ad559941293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15705603$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Ersoz, H O</creatorcontrib><creatorcontrib>Ukinc, K</creatorcontrib><creatorcontrib>Baykan, M</creatorcontrib><creatorcontrib>Erem, C</creatorcontrib><creatorcontrib>Durmus, I</creatorcontrib><creatorcontrib>Hacihasanoglu, A</creatorcontrib><creatorcontrib>Telatar, M</creatorcontrib><title>Effect of low-dose metoprolol in combination with sibutramine therapy in normotensive obese patients: a randomized controlled study</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><description>OBJECTIVE:
Sibutramine is an effective appetite suppresser agent, but treatment is often complicated with side effects, including palpitations and hypertension. In this study, we aimed to assess the effect of low-dose cardio-selective beta blocker combination with sibutramine treatment.
METHODS:
In total, 57 obese subjects were enrolled in the study and separated into two groups in order to receive sibutramine 10 mg/day plus placebo (group P) or sibutramine 10 mg/day plus metoprolol 25 mg/day (group M). Patients were evaluated in the beginning and at the end of the third month with anthropometric measurements, biochemical analysis, peripheral insulin resistance, and ambulatory 24 h blood pressure monitoring. Side effects were evaluated with a visual analog scale.
RESULTS:
During the study period, the drop-out rate was significantly higher in group P compared with group M (55 and 21%, respectively,
P
=0.014). Palpitations and headache were prominent symptoms in group P. Diastolic blood pressure (78.6±11.6 and 70.6±4.8 mmHg, respectively,
P
=0.013) and mean heart rate (84.3±6.1 and 75.8±8.4 beats/min, respectively,
P
=0.003) were significantly higher in group P compared with group M at the end of the third month. Weight loss was similar between the two groups (100.9±11.5 to 91.8±12.8 kg for group P,
P
<0.0001 and 97.9±13.2 to 88.9±13.8 kg for group M,
P
<0.0001). We did not find any deleterious effect of metoprolol on metabolic parameters.
CONCLUSION:
Addition of low-dose metoprolol to sibutramine therapy increased patient compliance to the treatment, and decreased the frequency and severity of side effects including hypertension and palpitations, without decreasing the drug efficacy or causing significant deleterious changes in metabolic parameters.</description><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biochemical analysis</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Coronary vessels</subject><subject>Drug dosages</subject><subject>Epidemiology</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Health Promotion and Disease Prevention</subject><subject>Heart rate</subject><subject>Hypertension</subject><subject>Insulin resistance</subject><subject>Internal Medicine</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metabolism</subject><subject>Obesity</subject><subject>Patients</subject><subject>Pharmacology. Drug treatments</subject><subject>Public Health</subject><subject>Side effects</subject><subject>Vein & artery diseases</subject><subject>Weight control</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNp1kc-P1CAUx4nRxHH16s2EmOits9CWAt42m_VHsokXPTeUPnZoWhiBuhmv_uO-yYyuHgwHCO_7_fAeX0JecrblrFGXedr6KW6ZYrWQ7SOy4a3sKtFq-ZhsWMNkxUQnnpJnOU-MMSFYvSE_b5wDW2h0dI731Rgz0AVK3Kc4x5n6QG1cBh9M8THQe192NPthLcksPgAtO0hmfzjqQkxLLBCy_w40DoCgPboglPyOGppMGOPif8CIxFAQP-Mxl3U8PCdPnJkzvDjvF-Tr-5sv1x-r288fPl1f3Va2VbpUg26bjg9Gq65rusF1tZJONMY4I4zTjoMVdW0tt6MYtTQNKCtbMwqhdctr3VyQ1ycuDvdthVz6Ka4p4JN9zXUtFZcCRduT6M7M0PvgIs5qcY2weOwcnMf7K65Ui13pBg1v_zLswMxll-O8Hj8s_ys8k22KOSdw_T75xaRDz1l_TLDPU48J9ucE0fDm3K_J1swOv9D6_OASEgNlR_DlSZexFO4gPcz1X_KrkwNzXRP8Qf6u_wJa4Lha</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>Ersoz, H O</creator><creator>Ukinc, K</creator><creator>Baykan, M</creator><creator>Erem, C</creator><creator>Durmus, I</creator><creator>Hacihasanoglu, A</creator><creator>Telatar, M</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20040301</creationdate><title>Effect of low-dose metoprolol in combination with sibutramine therapy in normotensive obese patients: a randomized controlled study</title><author>Ersoz, H O ; Ukinc, K ; Baykan, M ; Erem, C ; Durmus, I ; Hacihasanoglu, A ; Telatar, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-b94361ba986636bf6287f53aafa5af9f1ec522cc1cd5d97a3e8c74ad559941293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biochemical analysis</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood pressure</topic><topic>Body mass index</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Coronary vessels</topic><topic>Drug dosages</topic><topic>Epidemiology</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Health Promotion and Disease Prevention</topic><topic>Heart rate</topic><topic>Hypertension</topic><topic>Insulin resistance</topic><topic>Internal Medicine</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Metabolism</topic><topic>Obesity</topic><topic>Patients</topic><topic>Pharmacology. Drug treatments</topic><topic>Public Health</topic><topic>Side effects</topic><topic>Vein & artery diseases</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ersoz, H O</creatorcontrib><creatorcontrib>Ukinc, K</creatorcontrib><creatorcontrib>Baykan, M</creatorcontrib><creatorcontrib>Erem, C</creatorcontrib><creatorcontrib>Durmus, I</creatorcontrib><creatorcontrib>Hacihasanoglu, A</creatorcontrib><creatorcontrib>Telatar, M</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database (ProQuest)</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ersoz, H O</au><au>Ukinc, K</au><au>Baykan, M</au><au>Erem, C</au><au>Durmus, I</au><au>Hacihasanoglu, A</au><au>Telatar, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of low-dose metoprolol in combination with sibutramine therapy in normotensive obese patients: a randomized controlled study</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><date>2004-03-01</date><risdate>2004</risdate><volume>28</volume><issue>3</issue><spage>378</spage><epage>383</epage><pages>378-383</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>OBJECTIVE:
Sibutramine is an effective appetite suppresser agent, but treatment is often complicated with side effects, including palpitations and hypertension. In this study, we aimed to assess the effect of low-dose cardio-selective beta blocker combination with sibutramine treatment.
METHODS:
In total, 57 obese subjects were enrolled in the study and separated into two groups in order to receive sibutramine 10 mg/day plus placebo (group P) or sibutramine 10 mg/day plus metoprolol 25 mg/day (group M). Patients were evaluated in the beginning and at the end of the third month with anthropometric measurements, biochemical analysis, peripheral insulin resistance, and ambulatory 24 h blood pressure monitoring. Side effects were evaluated with a visual analog scale.
RESULTS:
During the study period, the drop-out rate was significantly higher in group P compared with group M (55 and 21%, respectively,
P
=0.014). Palpitations and headache were prominent symptoms in group P. Diastolic blood pressure (78.6±11.6 and 70.6±4.8 mmHg, respectively,
P
=0.013) and mean heart rate (84.3±6.1 and 75.8±8.4 beats/min, respectively,
P
=0.003) were significantly higher in group P compared with group M at the end of the third month. Weight loss was similar between the two groups (100.9±11.5 to 91.8±12.8 kg for group P,
P
<0.0001 and 97.9±13.2 to 88.9±13.8 kg for group M,
P
<0.0001). We did not find any deleterious effect of metoprolol on metabolic parameters.
CONCLUSION:
Addition of low-dose metoprolol to sibutramine therapy increased patient compliance to the treatment, and decreased the frequency and severity of side effects including hypertension and palpitations, without decreasing the drug efficacy or causing significant deleterious changes in metabolic parameters.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><doi>10.1038/sj.ijo.0802574</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2004-03, Vol.28 (3), p.378-383 |
| issn | 0307-0565 1476-5497 |
| language | eng |
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| source | Nature |
| subjects | Arterial hypertension. Arterial hypotension Biochemical analysis Biological and medical sciences Blood and lymphatic vessels Blood pressure Body mass index Cardiology. Vascular system Cardiovascular disease Clinical manifestations. Epidemiology. Investigative techniques. Etiology Coronary vessels Drug dosages Epidemiology General and cellular metabolism. Vitamins Health Promotion and Disease Prevention Heart rate Hypertension Insulin resistance Internal Medicine Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolism Obesity Patients Pharmacology. Drug treatments Public Health Side effects Vein & artery diseases Weight control |
| title | Effect of low-dose metoprolol in combination with sibutramine therapy in normotensive obese patients: a randomized controlled study |
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