Body mass index (BMI) in Turner syndrome before and during growth hormone (GH) therapy

OBJECTIVE: To study whether body mass index (BMI) is different in girls with Turner syndrome (TS) compared to normal girls, and whether BMI in TS is affected by growth hormone (GH) treatment. DESIGN: A retrospective cross-sectional study. SUBJECTS: 2468 girls with TS enrolled in the National Coopera...

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Bibliographic Details
Published in:International Journal of Obesity 2000-02, Vol.24 (2), p.232-235
Main Authors: Blackett, P.R, Rundle, A.C, Frane, J, Blethen, S.L
Format: Article
Language:English
Subjects:
Age
Biological and medical sciences
Body composition
Body mass index
children
Children & youth
cross-sectional studies
Enrollments
Genetic disorders
girls
Growth hormones
Health sciences
Hormones. Endocrine system
Medical sciences
metabolic diseases
monitoring
Obesity
patients
Pediatrics
Pharmacology. Drug treatments
somatotropin
therapeutics
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Summary:OBJECTIVE: To study whether body mass index (BMI) is different in girls with Turner syndrome (TS) compared to normal girls, and whether BMI in TS is affected by growth hormone (GH) treatment. DESIGN: A retrospective cross-sectional study. SUBJECTS: 2468 girls with TS enrolled in the National Cooperative Group Study (NCGS), a collaborative surveillance study for assessing GH-treated children. MEASUREMENTS: BMI and BMI standard deviation score (BMI SDS) at baseline and during GH treatment were computed from height and weight data. RESULTS: BMI in TS patients increases with age as expected. However, BMI SDS increased starting at about age 9 y. A similar pattern of increase in BMI SDS was observed after each year of GH treatment for up to 4 y, but GH treatment did not change the magnitude of increase. BMI and BMI SDS curves before and during GH treatment were essentially superimposable. CONCLUSION: These findings suggest that mechanisms specific for TS are responsible for the age-related increase in BMI SDS. This increase was unaffected by GH treatment.
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0801119