Lack of insulin inhibition on insulin secretion in non-diabetic morbidly obese patients

OBJECTIVE:: Insulin inhibition of insulin secretion has been described in normal lean subjects. In this study, we examined whether this phenomenon also occurs in the morbidly obese who often have severe peripheral insulin resistance. SUBJECTS:: Twelve obese patients, normotolerant to glucose (8 F/4...

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Bibliographic Details
Published in:International Journal of Obesity 2001-06, Vol.25 (6), p.798-804
Main Authors: MUSCELLI, E, PEREIRA, J. A, LAZARIN, Mact, DA SILVA, Ca, PAREJA, J. C, SAAD, M. J. A
Format: Article
Language:English
Subjects:
Associated diseases and complications
Biological and medical sciences
Blood pressure
Body mass index
Calorimetry
Cardiovascular disease
Catheters
Diabetes
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Feedback
Glucose
Ingestion
Insulin resistance
Medical sciences
Metabolism
Obesity
Peptides
Plasma
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Summary:OBJECTIVE:: Insulin inhibition of insulin secretion has been described in normal lean subjects. In this study, we examined whether this phenomenon also occurs in the morbidly obese who often have severe peripheral insulin resistance. SUBJECTS:: Twelve obese patients, normotolerant to glucose (8 F/4 M, body mass index (BMI)=54.8±2.5 kg/m2 , 39 y) and 16 lean control subjects (10 F/6 M, BMI=22.0±0.5 kg/m2 , 31 y). DESIGN AND MEASUREMENTS:: An experimental study using various parameters, including an euglycemic hyperinsulinemic clamp (280 pmol/min/m2 of body surface), an oral glucose tolerance test (OGTT), electrical bioimpedance and indirect calorimetry. RESULTS:: The obese subjects were insulin resistant (M=19.8±1.6 vs 48.7±2.6 μmol/min kg FFM, P
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0801607