Differential clinical expression of multiple symmetric lipomatosis in men and women

BACKGROUND: Multiple symmetric lipomatosis (MSL) is a rare disease characterised by the growth of uncapsulated masses of adipose tissue. MSL is associated with high ethanol intake and complicated by somatic and autonomic neuropathy and the infiltration of adipose tissue at the mediastinal level. To...

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Bibliographic Details
Published in:International Journal of Obesity 2003-11, Vol.27 (11), p.1419-1422
Main Authors: Busetto, L, Sträter, D, Enzi, G, Coin, A, Sergi, G, Inelmen, E.M, Pigozzo, S
Format: Article
Language:English
Subjects:
Adipose tissue
alcohol drinking
Alcohol use
Biological and medical sciences
Body fat
Cholesterol
Dermatology
Epidemiology
Ethanol
Females
Health Promotion and Disease Prevention
High density lipoprotein
high density lipoprotein cholesterol
Internal Medicine
legs
Longitudinal studies
low density lipoprotein cholesterol
Males
mediastinum
Medical sciences
Medicine
Medicine & Public Health
men
Metabolic Diseases
Metabolism
Morphology
Obesity
patients
peripheral nervous system diseases
Public Health
Tumors of the skin and soft tissue. Premalignant lesions
Uric acid
Women
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Summary:BACKGROUND: Multiple symmetric lipomatosis (MSL) is a rare disease characterised by the growth of uncapsulated masses of adipose tissue. MSL is associated with high ethanol intake and complicated by somatic and autonomic neuropathy and the infiltration of adipose tissue at the mediastinal level. To date, the disease is considered as largely more prevalent in men. OBJECTIVE: To provide a detailed description of the clinical aspects of MSL in women. PATIENTS: A total of 11 women and 58 men with MSL. MEASUREMENTS: Morphological aspect of patient, location of the lipomatous masses, alcohol intake, extension of lipomatous tissue to the mediastinum, association with somatic and autonomic neuropathy, and metabolic profile. RESULTS: All female patients had the obesity-like appearance of type II MSL and the most frequent locations of lipomatous masses in women were at the proximal arms (90.9%) and legs (54.5%). Very few female patients (27.3%) presented with the submental deposition of lipomatous tissue typical of both type I (97.3%; P
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0802427