Ophthalmic Microemulsion: Formulation Design and Process Optimization

Because of this characteristic, they tend to adsorb at the water-oil interface. [...]the API is needed to dissolve oil under continuous stirring at elevated temperature. [...]on the bases of the above results it is concluded to run the secondary homogenization in the recirculation loop at least for...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2018-12, Vol.11 (12), p.5474-5482
Main Authors: Bodkhe, Atul Arvind, Bedi, Ramandeep Singh, Upadhayay, Ashutosh, Kale, Mohan K.
Format: Article
Language:English
Subjects:
Anatomy & physiology
Cellulose
Drug delivery systems
Drug dosages
Microemulsions
Physical chemistry
Physiology
R&D
Research & development
Surfactants
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Summary:Because of this characteristic, they tend to adsorb at the water-oil interface. [...]the API is needed to dissolve oil under continuous stirring at elevated temperature. [...]on the bases of the above results it is concluded to run the secondary homogenization in the recirculation loop at least for 10 passes to achieve the desired droplet size. [...]on the bases of the above results it is concluded to run the secondary homogenization at about 60-70 C to achieve the desired droplet size.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2018.00998.8