Effects of Oxidative Stress on Alzheimer's Disease, Haematological Perspective

[...]this review article is designed to unearth the effect of oxidative stress in AD patients and incite leading researchers to generate database that will help in understand the relationship between oxidative stress and haematological parameters especially in AD patients. [...]providing a link betw...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2018-09, Vol.11 (9), p.3881-3886
Main Authors: Al-Hatamleh, Mohammad Ahmed Issa, Al-Shajrawi, Omar Mahmoud, Khan, Saif Ullah, Nadeem, Muhammad Ilyas, Simbak, Nordin Bin, Latif, Ahmad Zubaidi A., Baig, Atif Amin, Ariff, Tengku Mohammad
Format: Article
Language:English
Subjects:
Alzheimer's disease
Anemia
Blood
Cognition & reasoning
Deoxyribonucleic acid
DNA
Erythrocytes
Fatty acids
Free radicals
Hematology
Homeostasis
Mitochondrial DNA
Neurodegeneration
Oxidation
Oxidative stress
Pathogenesis
Proteins
Researchers
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Summary:[...]this review article is designed to unearth the effect of oxidative stress in AD patients and incite leading researchers to generate database that will help in understand the relationship between oxidative stress and haematological parameters especially in AD patients. [...]providing a link between the membrane and the cytoskeleton accountable for maintaining the cell shape, and providing for the reactions of cytosolic proteins with the membrane through the amino terminal region that emerges into the cytosol. The excessive levels of ROS can lead to damage cellular proteins including cytoskeletal proteins and ultimately disrupting GI tract barrier resulting an increase in gut permeability which contributes to inflammation in a variety of GI tract diseases84, 85. [...]oxidative stress resulting in AD patients can lead to GI disorders including malabsorption which leads to deficiency of important nutrients in the body including haematinic factors i.e., minerals and vitamins important to erythropoiesis. [...]only two studies have been shown this relationship and discussed it in general. [...]it can be suggested here the that more research investigations are needed to establish a more comprehensive evidences on the relationship of oxidative stress and anaemia (Table 1).
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2018.00711.4