Serum bFGF levels are reduced in Japanese overweight men and restored by a 6-month exercise education

OBJECTIVE: To investigate whether the changes in vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) concentrations before and after weight reduction in Japanese overweight men are associated with changes in body mass index (BMI), visceral, subcutaneous fat, VO2 and w...

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Bibliographic Details
Published in:International Journal of Obesity 2003-11, Vol.27 (11), p.1325-1331
Main Authors: Seida, A, Wada, J, Kunitomi, M, Tsuchiyama, Y, Miyatake, N, Fujii, M, Kira, S, Takahashi, K, Shikata, K, Makino, H
Format: Article
Language:English
Subjects:
angiogenic proteins
atherosclerosis
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
blood serum
Body fat
Body mass index
Cardiology. Vascular system
Computed tomography
correlation
Education
Epidemiology
equations
exercise
fibroblast growth factor 2
Health Promotion and Disease Prevention
Insulin resistance
Internal Medicine
Medical sciences
Medicine
Medicine & Public Health
men
Metabolic Diseases
Obesity
overweight
Peptides
Public Health
regression analysis
subcutaneous fat
Vascular endothelial growth factor
vascular endothelial growth factors
visceral fat
weight loss
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Summary:OBJECTIVE: To investigate whether the changes in vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) concentrations before and after weight reduction in Japanese overweight men are associated with changes in body mass index (BMI), visceral, subcutaneous fat, VO2 and work rate (WR) at ventilatory threshold (VT). DESIGN: Cross-sectional and longitudinal clinical intervention study with exercise education. SUBJECTS: In total, 30 Japanese overweight men (BMI, 29.0±2.2 kg/m(2)) and 31 normal-weight men (BMI, 22.5±1.6 kg/m(2)) at baseline were enrolled: 30 overweight men (BMI, 29.0±2.2 kg/m(2)) were further enrolled into a 6-month exercise program. MEASUREMENTS: Fat distribution evaluated by visceral fat (V) and subcutaneous fat (S) areas measured with computed tomography scanning at umbilical levels, angiogenic peptides including VEGF and bFGF, exercise tests at baseline and after 6 months. RESULTS: In normal-weight and overweight subjects at baseline, VEGF positively correlated with S area (r=0.350, P=0.007) but not with V area. In contrast, bFGF negatively correlated with BMI (r=-0.619, P
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0802408