Associations between a polymorphism in the 11 beta hydroxysteroid dehydrogenase type I gene and body composition

• Published in: International Journal of Obesity 2003-08, Vol.27 (8), p.983-986
• Main Authors: Gelernter-Yaniv, L, Feng, N, Sebring, N.G, Hochberg, Z, Yanovski, J.A
• Format: Article
• Language: English
• Subjects: adenine; Analysis of covariance; Biological and medical sciences; blood lipids; Body composition; Body fat; Body mass index; children; Dehydrogenase; Dehydrogenases; Endocrinology; Epidemiology; genes; Genetic aspects; genetic polymorphism; Genetic polymorphisms; Genotype & phenotype; Health aspects; Health Promotion and Disease Prevention; heterozygosity; homozygosity; Hormones; Insulin resistance; Internal Medicine; introns; Investigative techniques, diagnostic techniques (general aspects); Lipids; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolites; Obesity; Obesity in children; Overweight; Oxidoreductases; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Pediatrics; Polymorphism; Public Health; Risk factors; short-communication; waist circumference; waist-to-hip ratio
• ISSN: 0307-0565; 1476-5497
• DOI: 10.1038/sj.ijo.0802327

We investigated 11 beta hydroxysteriod dehydrogenase type 1 (11βHSD-1) sequence variants in 103 healthy overweight (BMI >2 s.d.) and 160 nonoverweight (BMI -2 to +2 SD) children to examine the associations between body composition and 11βHSD-1 polymorphisms. A total of 4.3% of children were homozygous and 30.0% heterozygous for an adenine insertion in intron 3 (ins4436A). By ANCOVA (adjusting for age, sex, race, and height), BMI-s.d. differed according to ins4436A genotype (P