Protective Effect of Ixora Coccinea Flowers against Cadmium Chloride induced Nephrotoxicity Model in Rats

The exposure to CdCl2 exhibit marked destruction in kidney function characterized by decrease in the body weight, increase in kidney weight and increase in serum creatinine, urea and uric acid levels, decrease of total protein levels and histopathological variations. Traditional/folklore drug practi...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2018-11, Vol.11 (11), p.4949-4952
Main Authors: Salam, B Abdul, Joshi, Himanshu, Gururaja, M. P, Shama, K Prasanna, D'souza, Ullas P, Rizwana, Kadeejath, Ali, Saneen
Format: Article
Language:English
Subjects:
Albinism
Animals
Cadmium
Chloride
Drug dosages
Kidneys
Literature reviews
Medical research
Phytochemicals
Proteins
Rodents
Studies
Uric acid
Variance analysis
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Summary:The exposure to CdCl2 exhibit marked destruction in kidney function characterized by decrease in the body weight, increase in kidney weight and increase in serum creatinine, urea and uric acid levels, decrease of total protein levels and histopathological variations. Traditional/folklore drug practitioners claim that Ixora coccinea removes heavy metals i.e lead, cadmium and mercury from contaminated water and the literature survey also indicates that it possesses several antioxidant principles5. [...]we hypothesise that this plant may also have nephroprotective properties. [...]the probable mechanism of nephroprotection by Ixora coccinea could be due to its antioxidant and free radical-scavenging property. [...]an effort was made to evaluvate the nephroprotective potential of the aqueous extract of the flowers of Ixora coccinea against CdCl2 induced nephrotoxicity.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2018.00901.0