Synergistic Molecular Effect of BDNF, ApoE and MTHFR in inducing Depression in Alzheimer's Disease

A population based investigation exhibited that the presence of the ApoE e4 allele anticipated future LLD35. Since depression might be a prodromal symptom of dementia, the examination rejected depressed subjects who later acquired dementia, thus featuring the relationship between ApoE e4 and LLD36....

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2018-10, Vol.11 (10), p.4317-4323
Main Authors: Mir, Zainab, Baig, Atif Amin, Rosliza, Naeem, Behroz, Nadeem, Ilyas Muhammad, Simbak, Nordin Bin, Zubaidi, A L A, Ariff, Tengku Mohammad, Khalili, M R, Kamal, Mohammad Amjad
Format: Article
Language:English
Subjects:
Aging
Alzheimer's disease
Biomarkers
Blood pressure
Brain
Dementia
Diabetes
Genes
Hypertension
Memory
Mental depression
Metabolism
Neurobiology
Neurosciences
Pathology
Patients
Polymorphism
Studies
Systematic review
Tomography
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Summary:A population based investigation exhibited that the presence of the ApoE e4 allele anticipated future LLD35. Since depression might be a prodromal symptom of dementia, the examination rejected depressed subjects who later acquired dementia, thus featuring the relationship between ApoE e4 and LLD36. In the studies wherein an affiliation was discovered, Asian populaces were appeared to be at a more serious danger of developing depression that was connected to the MTHFR C677T polymorphism contrasted with Caucasian populaces, and ethnicity was decidedly related with the chances proportions42,43. [...]a current report investigated the impacts of gene condition cooperations and uncovered that the MTHFR C677T polymorphism associated with traumatic childhood occasions to increase the risk of recurrence of depression in patients following a 5.5-year follow-up period. The recurrence of the T allele is significantly higher in Asians than it is in Caucasians48. [...]the eating methodologies of AD patients in these two populaces are diverse in light of provincial and ethnic varieties, leading to different levels of patient presentation to vitamin B12, folate, and homocysteine. [...]in light of the fact that the MTHFR C677T polymorphism is connected to direct hyper homocysteinemia, it is conceivable that expanded homocysteine levels may potentiate amyloid depositions and this may cause an increase in cytosolic calcium, increased oxidative stress, and debilitations in DNA repair that could eventually lead to neuron apoptosis[51].
ISSN:0974-3618
0974-306X
DOI:10.5958/0974-360X.2018.00790.4