Preparation and Identification of some new Compounds 1, 3, 4-Oxadiazole derivatives using Grinding Technique

• Published in: Research journal of pharmacy and technology 2018-10, Vol.11 (10), p.4272-4276
• Main Authors: Khidir, M. Muhammed, Sulaiman, H. Ayad, Ismael, T. Nihad
• Format: Article
• Language: English
• Subjects: Acids; Chromatography; Ethanol; Green chemistry; Identification; Iodine
• ISSN: 0974-3618; 0974-360X; 0974-306X
• DOI: 10.5958/0974-360X.2018.00783.7

General procedure for the preparation of benzimidazole acetic acid hydrazide(2): The solution of ethyl benzimidazole acetate (1) (0.04 mole) in ethanol (25 ml) was mixed with hydrazine hydrate (99%) (0.04 mole) and refluxed for (4 hr), completion of the reaction was monitored by (TLC), The excess of solvent was removed by distillation and the contents were added to excess of water. Green chemistry is the need of today and light of future which gives a precious idea for the scientifically based environmental protection. chemists, researchers and pharmaceutical companies must be use to consider the principles of green chemistry while designing the reaction mechanism and selecting catalyst. by applying green chemistry procedures, we can minimize the waste materials, reduce the use of toxic chemicals , maintain the atom economy and save the environment which is heritage of our next generation. The IR spectra of benzimidazole acetic acid hydrazide (2) shows absorption bands at (1650 cm-1) (C=O amide), this is the frequency at hydrazide it is falling at lower frequency [18], because of existence the resonas in the hydrazide, accordingly minimize the constant power shows absorption bands at (3392cm-1) (NH), (3015cm-1) (C-H aromatic), (1586cm-1) (C=N).