Platelet P-selectin and GPIIb/IIIa expression after liver transplantation and resection

Platelet dysfunction contributes to haemostatic defects, possibly leading to bleeding complications. We hypothesised that liver transplantation and liver resection, together with portal clamping time, might be a potential stimulus for platelet activation. Therefore, we determined the expression of p...

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Published in:Transplant international 2004-09, Vol.17 (8), p.442
Main Authors: Becker, Thomas, Jüttner, Björn, Holger-Andreas Elsner, Andreas Meyer zu Vilsendorf, Bornscheuer, Albrecht, Nashan, Björn, Brandl, Michael, Klempnauer, Jürgen, Piepenbrock, Siegfried, Scheinichen, Dirk
Format: Article
Language:English
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Summary:Platelet dysfunction contributes to haemostatic defects, possibly leading to bleeding complications. We hypothesised that liver transplantation and liver resection, together with portal clamping time, might be a potential stimulus for platelet activation. Therefore, we determined the expression of platelet GPIIb/IIIa and P-selectin, representing important platelet activation markers, and the thrombopoietin (TPO) serum level after transplantation and resection. Twenty patients [ten that had undergone orthotopic liver transplantation (OLT), ten with liver resection (LRX)] were included in the study. From sequential venous blood samples, surface expression of GPIIb/IIIa and P-selectin was quantified by flow cytometry, and TPO serum levels were determined by ELISA. Baseline GPIIb/IIIa receptor expression on circulating platelets was significantly reduced in the OLT group compared to the LRX group and healthy volunteers. GPIIb/IIIa expression after activation with TRAP-6 increased significantly (P
ISSN:0934-0874
1432-2277
DOI:10.1007/s00147-004-0747-y