Altered blood procalcitonin, C-reactive protein, and leucocytes count in association with canine parvovirus (CPV) enteritis

Canine parvovirus enteritis is a highly contagious viral disease which causes high morbidity and mortality rates in young puppies. This study aimed to evaluate the diagnostic value of procalcitonin as an inflammatory biomarker as compared with C-reactive protein and total leucocyte count in canine p...

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Bibliographic Details
Published in:Comparative clinical pathology 2019-08, Vol.28 (4), p.1095-1099
Main Authors: Kubesy, A. A., Rakha, G. M., Salem, Shaymaa I., Jaheen, A. H.
Format: Article
Language:English
Subjects:
Biomarkers
C-reactive protein
Cell size
Dogs
Enteritis
Erythrocytes
Hematology
Hemoglobin
Inflammation
Leukocytes
Leukopenia
Lymphopenia
Medicine
Medicine & Public Health
Monocytosis
Morbidity
Neutropenia
Oncology
Original Article
Parvoviruses
Pathology
Procalcitonin
Proteins
Viral diseases
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Summary:Canine parvovirus enteritis is a highly contagious viral disease which causes high morbidity and mortality rates in young puppies. This study aimed to evaluate the diagnostic value of procalcitonin as an inflammatory biomarker as compared with C-reactive protein and total leucocyte count in canine parvovirus enteritis. This study was carried out on 41 dogs constituting 14 apparently healthy dogs used as a control and 27 dogs affected with canine parvovirus enteritis. Inflammatory biomarkers analysis showed a significant increase in C-reactive protein, a significant decrease in leucocytes counts, and an insignificant increase in procalcitonin level. Hematological profile showed a significant decrease in red blood cells count, hemoglobin content, packed cell volume %, mean corpuscular hemoglobin, and an insignificant increase in the mean corpuscular volume, and significant leucopenia, associated with neutropenia, lymphopenia, and monocytosis in addition to significant hypoproteinemia in canine parvovirus enteritis. Analysis of C-reactive protein concentration is found to be more effective than leucocytes count and procalcitonin concentration as an inflammatory biomarker in canine parvovirus enteritis.
ISSN:1618-5641
1618-565X
DOI:10.1007/s00580-019-02941-y