Loading…
Particle-induced circulatory disturbances in transplanted rhesus macaque kidneys
We have demonstrated the presence of crystalline particles in University of Wisconsin (UW) solution used to perfuse rhesus monkey kidney transplants. These particles were visible in obstructed blood vessels and associated with immediate graft thrombosis and necrosis. This occurred in 25.7% of kidney...
Saved in:
| Published in: | Transplant international 2003-08, Vol.16 (8), p.491-496 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | |
| container_end_page | 496 |
| container_issue | 8 |
| container_start_page | 491 |
| container_title | Transplant international |
| container_volume | 16 |
| creator | Hubbard, William J Hutchings, Anne Eckhoff, Devin Contreras, Juan Wilkins, Martha Thomas, Francis T Clements, Michael Thomas, Judith M |
| description | We have demonstrated the presence of crystalline particles in University of Wisconsin (UW) solution used to perfuse rhesus monkey kidney transplants. These particles were visible in obstructed blood vessels and associated with immediate graft thrombosis and necrosis. This occurred in 25.7% of kidneys perfused with UW solution and transplanted into young, unsensitized recipients. Two molecular species of crystals were defined by mass spectrometry. The particle size ranged from 3 to greater than 100 microm, with a preponderance of particles less than 25 microm in diameter. Such particles are not removed by 40-microm filtration, but can be removed by centrifugation. With extensive use of UW solution for organ storage, the potential for particle-induced damage in small vessels in both experimental and human transplants needs to be carefully scrutinized. |
| doi_str_mv | 10.1007/s00147-003-0624-0 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_219619766</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>707923591</sourcerecordid><originalsourceid>FETCH-LOGICAL-c160t-691e8c88422fc39f678176e70e3b32e4924f0502c1b64e9893e690a9cfabdd113</originalsourceid><addsrcrecordid>eNpFkEtLAzEUhYMotlZ_gBsZ3EfvTdI8llJ8QcEudB0ymTs4dTqtycyi_94pLbi6cPnOOfAxdovwgADmMQOgMhxActBCcThjU1RScCGMOWdTcHJ8WqMm7CrnNQAIO4dLNkFh0Vmtp2y1CqlvYku86aohUlXEJsWhDf027Yuqyf2QytBFykXTFX0KXd61oetHMH1THnKxCTH8DlT8NFVH-3zNLurQZro53Rn7enn-XLzx5cfr--JpySNq6Ll2SDZaq4Soo3S1NhaNJgMkSylIOaFqmIOIWGpFzjpJ2kFwsQ5lVSHKGbs_9u7SdpzPvV9vh9SNk16g0-iM1iOERyimbc6Jar9LzSakvUfwB4X-qNCPCv1BoYcxc3cqHsoNVf-JkzP5BzfbbJU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219619766</pqid></control><display><type>article</type><title>Particle-induced circulatory disturbances in transplanted rhesus macaque kidneys</title><source>Alma/SFX Local Collection</source><creator>Hubbard, William J ; Hutchings, Anne ; Eckhoff, Devin ; Contreras, Juan ; Wilkins, Martha ; Thomas, Francis T ; Clements, Michael ; Thomas, Judith M</creator><creatorcontrib>Hubbard, William J ; Hutchings, Anne ; Eckhoff, Devin ; Contreras, Juan ; Wilkins, Martha ; Thomas, Francis T ; Clements, Michael ; Thomas, Judith M</creatorcontrib><description>We have demonstrated the presence of crystalline particles in University of Wisconsin (UW) solution used to perfuse rhesus monkey kidney transplants. These particles were visible in obstructed blood vessels and associated with immediate graft thrombosis and necrosis. This occurred in 25.7% of kidneys perfused with UW solution and transplanted into young, unsensitized recipients. Two molecular species of crystals were defined by mass spectrometry. The particle size ranged from 3 to greater than 100 microm, with a preponderance of particles less than 25 microm in diameter. Such particles are not removed by 40-microm filtration, but can be removed by centrifugation. With extensive use of UW solution for organ storage, the potential for particle-induced damage in small vessels in both experimental and human transplants needs to be carefully scrutinized.</description><identifier>ISSN: 0934-0874</identifier><identifier>EISSN: 1432-2277</identifier><identifier>DOI: 10.1007/s00147-003-0624-0</identifier><identifier>PMID: 12819866</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adenosine - blood ; Adenosine - chemistry ; Allopurinol - blood ; Allopurinol - chemistry ; Animals ; Crystallization ; Flow Cytometry ; Glutathione - blood ; Glutathione - chemistry ; Insulin - blood ; Insulin - chemistry ; Kidney - blood supply ; Kidney - pathology ; Kidney - surgery ; Kidney Transplantation - adverse effects ; Macaca mulatta ; Male ; Mass Spectrometry ; Necrosis ; Organ Preservation Solutions - chemistry ; Organ Preservation Solutions - metabolism ; Raffinose - blood ; Raffinose - chemistry ; Renal Circulation ; Thrombosis - chemically induced ; Transplantation, Homologous ; Ultrasonography, Doppler</subject><ispartof>Transplant international, 2003-08, Vol.16 (8), p.491-496</ispartof><rights>Copyright Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12819866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hubbard, William J</creatorcontrib><creatorcontrib>Hutchings, Anne</creatorcontrib><creatorcontrib>Eckhoff, Devin</creatorcontrib><creatorcontrib>Contreras, Juan</creatorcontrib><creatorcontrib>Wilkins, Martha</creatorcontrib><creatorcontrib>Thomas, Francis T</creatorcontrib><creatorcontrib>Clements, Michael</creatorcontrib><creatorcontrib>Thomas, Judith M</creatorcontrib><title>Particle-induced circulatory disturbances in transplanted rhesus macaque kidneys</title><title>Transplant international</title><addtitle>Transpl Int</addtitle><description>We have demonstrated the presence of crystalline particles in University of Wisconsin (UW) solution used to perfuse rhesus monkey kidney transplants. These particles were visible in obstructed blood vessels and associated with immediate graft thrombosis and necrosis. This occurred in 25.7% of kidneys perfused with UW solution and transplanted into young, unsensitized recipients. Two molecular species of crystals were defined by mass spectrometry. The particle size ranged from 3 to greater than 100 microm, with a preponderance of particles less than 25 microm in diameter. Such particles are not removed by 40-microm filtration, but can be removed by centrifugation. With extensive use of UW solution for organ storage, the potential for particle-induced damage in small vessels in both experimental and human transplants needs to be carefully scrutinized.</description><subject>Adenosine - blood</subject><subject>Adenosine - chemistry</subject><subject>Allopurinol - blood</subject><subject>Allopurinol - chemistry</subject><subject>Animals</subject><subject>Crystallization</subject><subject>Flow Cytometry</subject><subject>Glutathione - blood</subject><subject>Glutathione - chemistry</subject><subject>Insulin - blood</subject><subject>Insulin - chemistry</subject><subject>Kidney - blood supply</subject><subject>Kidney - pathology</subject><subject>Kidney - surgery</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Macaca mulatta</subject><subject>Male</subject><subject>Mass Spectrometry</subject><subject>Necrosis</subject><subject>Organ Preservation Solutions - chemistry</subject><subject>Organ Preservation Solutions - metabolism</subject><subject>Raffinose - blood</subject><subject>Raffinose - chemistry</subject><subject>Renal Circulation</subject><subject>Thrombosis - chemically induced</subject><subject>Transplantation, Homologous</subject><subject>Ultrasonography, Doppler</subject><issn>0934-0874</issn><issn>1432-2277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNpFkEtLAzEUhYMotlZ_gBsZ3EfvTdI8llJ8QcEudB0ymTs4dTqtycyi_94pLbi6cPnOOfAxdovwgADmMQOgMhxActBCcThjU1RScCGMOWdTcHJ8WqMm7CrnNQAIO4dLNkFh0Vmtp2y1CqlvYku86aohUlXEJsWhDf027Yuqyf2QytBFykXTFX0KXd61oetHMH1THnKxCTH8DlT8NFVH-3zNLurQZro53Rn7enn-XLzx5cfr--JpySNq6Ll2SDZaq4Soo3S1NhaNJgMkSylIOaFqmIOIWGpFzjpJ2kFwsQ5lVSHKGbs_9u7SdpzPvV9vh9SNk16g0-iM1iOERyimbc6Jar9LzSakvUfwB4X-qNCPCv1BoYcxc3cqHsoNVf-JkzP5BzfbbJU</recordid><startdate>200308</startdate><enddate>200308</enddate><creator>Hubbard, William J</creator><creator>Hutchings, Anne</creator><creator>Eckhoff, Devin</creator><creator>Contreras, Juan</creator><creator>Wilkins, Martha</creator><creator>Thomas, Francis T</creator><creator>Clements, Michael</creator><creator>Thomas, Judith M</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope></search><sort><creationdate>200308</creationdate><title>Particle-induced circulatory disturbances in transplanted rhesus macaque kidneys</title><author>Hubbard, William J ; Hutchings, Anne ; Eckhoff, Devin ; Contreras, Juan ; Wilkins, Martha ; Thomas, Francis T ; Clements, Michael ; Thomas, Judith M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c160t-691e8c88422fc39f678176e70e3b32e4924f0502c1b64e9893e690a9cfabdd113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adenosine - blood</topic><topic>Adenosine - chemistry</topic><topic>Allopurinol - blood</topic><topic>Allopurinol - chemistry</topic><topic>Animals</topic><topic>Crystallization</topic><topic>Flow Cytometry</topic><topic>Glutathione - blood</topic><topic>Glutathione - chemistry</topic><topic>Insulin - blood</topic><topic>Insulin - chemistry</topic><topic>Kidney - blood supply</topic><topic>Kidney - pathology</topic><topic>Kidney - surgery</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Macaca mulatta</topic><topic>Male</topic><topic>Mass Spectrometry</topic><topic>Necrosis</topic><topic>Organ Preservation Solutions - chemistry</topic><topic>Organ Preservation Solutions - metabolism</topic><topic>Raffinose - blood</topic><topic>Raffinose - chemistry</topic><topic>Renal Circulation</topic><topic>Thrombosis - chemically induced</topic><topic>Transplantation, Homologous</topic><topic>Ultrasonography, Doppler</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hubbard, William J</creatorcontrib><creatorcontrib>Hutchings, Anne</creatorcontrib><creatorcontrib>Eckhoff, Devin</creatorcontrib><creatorcontrib>Contreras, Juan</creatorcontrib><creatorcontrib>Wilkins, Martha</creatorcontrib><creatorcontrib>Thomas, Francis T</creatorcontrib><creatorcontrib>Clements, Michael</creatorcontrib><creatorcontrib>Thomas, Judith M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Transplant international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hubbard, William J</au><au>Hutchings, Anne</au><au>Eckhoff, Devin</au><au>Contreras, Juan</au><au>Wilkins, Martha</au><au>Thomas, Francis T</au><au>Clements, Michael</au><au>Thomas, Judith M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Particle-induced circulatory disturbances in transplanted rhesus macaque kidneys</atitle><jtitle>Transplant international</jtitle><addtitle>Transpl Int</addtitle><date>2003-08</date><risdate>2003</risdate><volume>16</volume><issue>8</issue><spage>491</spage><epage>496</epage><pages>491-496</pages><issn>0934-0874</issn><eissn>1432-2277</eissn><abstract>We have demonstrated the presence of crystalline particles in University of Wisconsin (UW) solution used to perfuse rhesus monkey kidney transplants. These particles were visible in obstructed blood vessels and associated with immediate graft thrombosis and necrosis. This occurred in 25.7% of kidneys perfused with UW solution and transplanted into young, unsensitized recipients. Two molecular species of crystals were defined by mass spectrometry. The particle size ranged from 3 to greater than 100 microm, with a preponderance of particles less than 25 microm in diameter. Such particles are not removed by 40-microm filtration, but can be removed by centrifugation. With extensive use of UW solution for organ storage, the potential for particle-induced damage in small vessels in both experimental and human transplants needs to be carefully scrutinized.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>12819866</pmid><doi>10.1007/s00147-003-0624-0</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0934-0874 |
| ispartof | Transplant international, 2003-08, Vol.16 (8), p.491-496 |
| issn | 0934-0874 1432-2277 |
| language | eng |
| recordid | cdi_proquest_journals_219619766 |
| source | Alma/SFX Local Collection |
| subjects | Adenosine - blood Adenosine - chemistry Allopurinol - blood Allopurinol - chemistry Animals Crystallization Flow Cytometry Glutathione - blood Glutathione - chemistry Insulin - blood Insulin - chemistry Kidney - blood supply Kidney - pathology Kidney - surgery Kidney Transplantation - adverse effects Macaca mulatta Male Mass Spectrometry Necrosis Organ Preservation Solutions - chemistry Organ Preservation Solutions - metabolism Raffinose - blood Raffinose - chemistry Renal Circulation Thrombosis - chemically induced Transplantation, Homologous Ultrasonography, Doppler |
| title | Particle-induced circulatory disturbances in transplanted rhesus macaque kidneys |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T12%3A05%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Particle-induced%20circulatory%20disturbances%20in%20transplanted%20rhesus%20macaque%20kidneys&rft.jtitle=Transplant%20international&rft.au=Hubbard,%20William%20J&rft.date=2003-08&rft.volume=16&rft.issue=8&rft.spage=491&rft.epage=496&rft.pages=491-496&rft.issn=0934-0874&rft.eissn=1432-2277&rft_id=info:doi/10.1007/s00147-003-0624-0&rft_dat=%3Cproquest_cross%3E707923591%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c160t-691e8c88422fc39f678176e70e3b32e4924f0502c1b64e9893e690a9cfabdd113%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=219619766&rft_id=info:pmid/12819866&rfr_iscdi=true |