Selective functionalization of ferrocenyl compounds using a novel solvent free synthetic method for the preparation of bioactive unsymmetrical ferrocenyl derivatives

A novel solvent free synthetic method has been designed by using rice husk ash (RHA) as solid support for the selective functionalization of ferrocenyl derivatives and described the synthesis of a 1,1′‐unsymmetrically bi‐functionalized ferrocenyl compounds for their biological evaluation. Single cry...

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Bibliographic Details
Published in:Applied organometallic chemistry 2019-04, Vol.33 (4), p.n/a
Main Authors: Ghosh, Avishek, Barik, Tulasi, Dewangan, Smriti, Majhi, Paresh Kumar, Sasamori, Takahiro, Mobin, Shaikh M., Giri, Santanab, Chatterjee, Saurav
Format: Article
Language:English
Subjects:
antibacterial
Biological effects
Chemical bonds
Chemistry
Crystal structure
Derivatives
ferrocenyl
Hydrazones
Hydrogen bonding
selective substitution
Single crystals
solvent free
Solvents
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Summary:A novel solvent free synthetic method has been designed by using rice husk ash (RHA) as solid support for the selective functionalization of ferrocenyl derivatives and described the synthesis of a 1,1′‐unsymmetrically bi‐functionalized ferrocenyl compounds for their biological evaluation. Single crystal X‐ray structural evaluation showed some interesting intra‐molecular hydrogen bonding interactions across the chains of the ferrocenyl molecule, while DFT calculation revealed the significance of the orientation between the two cyclopentadienyl rings for the hydrogen bonding interaction. Redox and antibacterial properties have been studied to understand the electronic and biological effect of different hydrazone system and their potential for future application. Novel solvent free synthetic method using rice husk ash as solid support for selective functionalization of ferrocenyl derivatives and synthesis of 1,1′‐unsymmetrically bi‐functionalized compounds and their antibacterial evaluation.
ISSN:0268-2605
1099-0739
DOI:10.1002/aoc.4838