Expression of transforming growth factor-beta and interferon gamma biomarkers after whole body gamma irradiation

Context: There are plenty of evidence that suggest that the potential high doses of radiation result in severe health effects to exposed individuals, although there is no consensus about the health impact of low dose of ionizing radiation (IR). Aims: This study aimed to discuss the effect a range of...

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Bibliographic Details
Published in:Journal of cancer research and therapeutics 2019-03, Vol.15 (8), p.135-139
Main Authors: Fardid, Reza, Ghahramani, Parisa, Mosleh-Shirazi, Mohammad-Amin, Kalantari, Tahereh, Behzad-Behbahani, Abbas, Kazemi, Elaheh, Okhovat, Mohammad-Ali
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biological markers
Biological response modifiers
Biomarkers - blood
Biomarkers - metabolism
Blood proteins
Bone morphogenetic proteins
Cytokines
Dose-Response Relationship, Radiation
Dosimetry
Environmental Exposure - adverse effects
Enzymes
Gamma rays
Gamma Rays - adverse effects
Gene expression
Gene Expression Regulation - radiation effects
Genes
Growth factors
Health
Immune system
Interferon
Interferon gamma
Interferon-gamma - blood
Interferon-gamma - metabolism
Ionizing radiation
Lymphocytes
Lymphocytes - metabolism
Lymphocytes - radiation effects
Male
Models, Animal
Nuclear energy
Occupational Exposure - adverse effects
Polymerase chain reaction
Proteins
Radiation (Physics)
Radiation therapy
Rats
Transforming Growth Factor beta - blood
Transforming Growth Factor beta - metabolism
Transforming growth factors
Tumor necrosis factor-TNF
Whole-Body Irradiation - adverse effects
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Summary:Context: There are plenty of evidence that suggest that the potential high doses of radiation result in severe health effects to exposed individuals, although there is no consensus about the health impact of low dose of ionizing radiation (IR). Aims: This study aimed to discuss the effect a range of IR doses on the changes of gene expression and serum protein levels of two immune factors transforming growth factor-β (TGF-β) and interferon gamma (IFN-γ) in rats. Findings from this study can be useful to develop a suitable biomarker for biological dosimetry applications. Subjects and Methods: After 24 h of irradiation of rats with the doses of 1000, 500, 100, 50, and 20 mGy, the gene expression of TGF-β and IFN-γ in lymphocytes was assessed using quantitative polymerase chain reaction. Besides, the protein level of these two factors in blood plasma was determined by enzyme-linked immunosorbent assay (ELISA) kits. Statistical Analysis Used: One-way analysis of variance Tukey-Kramer Multiple Comparisons Test was used. P
ISSN:0973-1482
1998-4138
DOI:10.4103/jcrt.JCRT_1324_16