Guest-host interactions of nanoconfined anti-cancer drug in metal-organic framework exposed by terahertz dynamics

A facile mechanochemical method was employed to accomplish one-pot encapsulation of anti-cancer drug 5-fluorouracil (5-FU as guest) in a metal-organic framework (HKUST-1 as host). Vibrational spectroscopy via inelastic neutron scattering was applied to probe guest-host interactions arising from nano...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-03, Vol.55 (27), p.3868-3871
Main Authors: Souza, Barbara E, Rudi, Svemir, Titov, Kirill, Babal, Arun S, Taylor, James D, Tan, Jin-Chong
Format: Article
Language:English
Subjects:
Cancer
Electron micrographs
Encapsulation
Inelastic scattering
Metal-organic frameworks
Neutron scattering
Neutrons
Spectrum analysis
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Summary:A facile mechanochemical method was employed to accomplish one-pot encapsulation of anti-cancer drug 5-fluorouracil (5-FU as guest) in a metal-organic framework (HKUST-1 as host). Vibrational spectroscopy via inelastic neutron scattering was applied to probe guest-host interactions arising from nanoscale confinement. We compare 5-FU@HKUST-1 derived from in situ and ex situ encapsulation. Guest-host interactions of mechanochemically synthesized drug@MOF composite systems revealed by inelastic neutron scattering.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc10089f