Results of In Vivo Biological Tests Performed on a Mg-0.8Ca Alloy

Biodegradable magnesium-based alloys shows good prospects in their use as biodegradable orthopedic materials. The aim of this study is to demonstrate good biocompatibility and lack of local and systemic toxicity of some experimental implants made by magnesium alloy type Mg-Ca 0,8 [%wt]. The study wa...

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Bibliographic Details
Published in:Key engineering materials 2017-07, Vol.745, p.50-61
Main Authors: Voinescu, Dan, Barbilian, Adrian, Adam, Razvan, Orban, Horia, Plopeanu, Elisa
Format: Article
Language:English
Subjects:
Biocompatibility
Biodegradability
Blood
Bone surgery
Calcium
Euthanasia
Evolution
Femur
Fibrosis
In vivo methods and tests
Liver
Magnesium alloys
Magnesium base alloys
Muscles
Rabbits
Surgical implants
Thigh
Tibia
Toxicity
Transplants & implants
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Summary:Biodegradable magnesium-based alloys shows good prospects in their use as biodegradable orthopedic materials. The aim of this study is to demonstrate good biocompatibility and lack of local and systemic toxicity of some experimental implants made by magnesium alloy type Mg-Ca 0,8 [%wt]. The study was conducted by implanting some experimental pins made by magnesium alloy type Mg-Ca 0,8 [%wt] in bone, proximal femur and intramedullary tibia, and in thigh muscle of the rabbits. Also, we follow the evolution of blood levels of Mg, Ca, blood counts, liver and kidney function. The evolution of the experience animals was followed for 6 weeks by radiologic imaging, and taking blood samples. After 6 weeks, we obtain after euthanasia of animal experience the harvest blood samples, and musculoskeletal tissue samples for histopathological examination. The histopathology results have not demonstrated peri-implant cytotoxicity, bone and muscle cells being viable. Fibrosis at tissue implant border was minimal showing a good integration. There were no pathological increases in blood levels of Mg and Ca, or changes in blood counts, as well as no change in renal or hepatic function. All this experimental results demonstrates that the magnesium alloy type Mg-Ca 0,8 [%wt] represent a promising solution in orthopedic surgery, proving to be safe, with a high degree of biocompatibility, and without toxic effects.
ISSN:1013-9826
1662-9795
1662-9795
DOI:10.4028/www.scientific.net/KEM.745.50