Chitosan oligosaccharide coated mesoporous silica nanoparticles for pH-stimuli responsive drug delivery applications

Biopolymer-coated drug delivery system with high drug-loading efficiency and pH-stimuli responsive drug release to the target site receives much research interest in cancer therapy. In this study, we have synthesized a marine biopolymer, namely chitosan oligosaccharide (COS) coated mesoporous silica...

Full description

Saved in:
Bibliographic Details
Published in:Journal of porous materials 2019-02, Vol.26 (1), p.217-226
Main Authors: Moorthy, Madhappan Santha, Hoang, Giang, Manivasagan, Panchanathan, Mondal, Sudip, Vy Phan, Thi Tuong, Kim, Hyehyun, Oh, Junghwan
Format: Article
Language:English
Subjects:
Biocompatibility
Biopolymers
Cancer
Cancer therapies
Catalysis
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Chitosan
Coating
Coordination compounds
Drug delivery systems
Fluorescence
Fourier transforms
Nanoparticles
Oligosaccharides
Physical Chemistry
Silicon dioxide
Stimuli
Synthesis
Therapy
Toxicity
X-ray diffraction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Biopolymer-coated drug delivery system with high drug-loading efficiency and pH-stimuli responsive drug release to the target site receives much research interest in cancer therapy. In this study, we have synthesized a marine biopolymer, namely chitosan oligosaccharide (COS) coated mesoporous silica nanoparticle (MSNs@COS NPs) system for pH-responsive drug delivery applications. The COS coating onto the silica nanoparticles was performed through metal–ligand complex coordination approaches. The prepared MSNs@COS NPs system were characterized by low-angle X-ray diffraction (XRD), Fourier-transform infrared (FTIR), N 2 adsorption–desorption and transmission electron microscopic (TEM), and thermogravimetric analyses. The COS-coated MSNs@COS NPs system shows high drug-loading capacity, good drug retention efficiency under physiological pH (pH 7.4) conditions, and an intracellular pH-responsive drug release behavior under acidic pH (pH 6.5, 5.0, and 4.0) environments. Furthermore, the biocompatibility and the intracellular uptake behavior of the MSNs@COS NPs system were evaluated by using MDA-MB-231 cells. The in vitro cytotoxicity and fluorescence microscopic analysis results evidenced that the synthesized MSNs@COS NPs system is biocompatible and could be readily taken up by MDA-MB-231 cells. Therefore, we believe that the proposed system could be applicable for pH-stimuli responsive controlled drug delivery applications in cancer therapy.
ISSN:1380-2224
1573-4854
DOI:10.1007/s10934-018-0646-8