Outcomes of Dosage Adjustments Used to Manage Antiretroviral Drug Interactions

Dosage adjustments are often used to manage HIV drug interactions, but little is known about their clinical significance. We examined patients from the Ontario HIV Cohort Study to assess the effects of dosage adjustments on plasma viral load. A significant reduction (0.67 log10 copies/mL) in viral l...

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Bibliographic Details
Published in:Clinical infectious diseases 2007-10, Vol.45 (7), p.933-936
Main Authors: Park-Wyllie, Laura Y., Levine, Mitchell A., Holbrook, Anne, Thabane, Lehana, Antoniou, Tony, Yoong, Deborah, Kam, Derek, Bayoumi, Ahmed M.
Format: Article
Language:English
Subjects:
Anti-Retroviral Agents - administration & dosage
Anti-Retroviral Agents - adverse effects
Anti-Retroviral Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral drugs
Antiretrovirals
Antiviral agents
Antivirals
Biological and medical sciences
Confidence intervals
Dosage
Dose-Response Relationship, Drug
Drug dosages
Drug Interactions
Drug therapy
Drug Therapy, Combination
Female
Health outcomes
HIV
HIV Infections - drug therapy
HIV/AIDS
Human immunodeficiency virus
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Longitudinal Studies
Male
Medical Audit
Medical sciences
Medications
Memory interference
Middle Aged
Ontario
Pharmacology. Drug treatments
Prescription drugs
Treatment Outcome
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral Load
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Summary:Dosage adjustments are often used to manage HIV drug interactions, but little is known about their clinical significance. We examined patients from the Ontario HIV Cohort Study to assess the effects of dosage adjustments on plasma viral load. A significant reduction (0.67 log10 copies/mL) in viral load was associated with adjustments to manage efavirenz-based interactions (95% confidence interval, -1.33 to -0.01) but was not observed after adjustments to manage rifabutin-based (difference in viral load, 0.03 log10 copies/mL; 95% confidence interval, -0.71 to 0.77) or nevirapine-based interactions (difference in viral load, 0.09 log10 copies/mL; 95% confidence interval, -0.83 to 1.01).
ISSN:1058-4838
1537-6591
DOI:10.1086/521252