1H spin-lattice relaxation in water solution of 209Bi counterparts of Gd3+contrast agents

• Published in: Molecular physics 2019-04, Vol.117 (7-8), p.927-934
• Main Authors: Kruk, Danuta, Umut, Evrim, Masiewicz, Elzbieta, Hermann, Petr, Scharfetter, Hermann
• Format: Article
• Language: English
• Subjects: Acids; Bismuth isotopes; Contrast agents; dynamics; Ethylenediamine; Ethylenediaminetetraacetic acids; Frequency ranges; Gadolinium; Magnetic resonance imaging; NMR; Nuclear magnetic resonance; Quadrupoles; relaxation; Spin-lattice relaxation
• ISSN: 0026-8976; 1362-3028
• DOI: 10.1080/00268976.2018.1517907

1 H spin-lattice relaxation studies of water solutions of Bismuth-ethylenediamine-tetraacetic acid (Bi-EDTA), Bismuth-ethylenediamine-tetrakis(methylenephosphonic) acid (Bi-EDTP), Bismuth-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (Bi-DOTA), Bismuth-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid) (Bi-DOTP) and Bismuth-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (Bi-DO3A) have been performed in order to compare Quadrupole Relaxation Enhancement (QRE) effects with Paramagnetic Relaxation Enhancement (PRE) from the perspective of exploiting the first one as a novel contrast mechanism for Magnetic Resonance Imaging (MRI). The selected compounds can be considered as 209 Bi counterparts of Gd 3+ complexes. The relaxation experiments have been performed in a broad frequency range of 5 kHz-30 MHz. The relaxation contribution associated with QRE has been extracted from the data and compared with PRE. Similarities and differences between the two effects have been discussed.