Toxicity to topical dimethyl sulfoxide (DMSO) when used as an extravasation antidote

DMSO is a dipolar, aprotic, hygroscopic solvent for which a large number of pharmacologic properties have been claimed. Topical DMSO is considered an effective and safe antidote to be used with topical cooling after extravasations of vesicant drugs. A case of toxicity after its use as an antidote is...

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Bibliographic Details
Published in:Pharmacy world and science 2002-10, Vol.24 (5), p.175
Main Authors: Creus, N, Mateu, J, Massó, J, Codina, C, Ribas, J
Format: Article
Language:English
Subjects:
Administration, Topical
Adult
Antidotes - adverse effects
Dimethyl Sulfoxide - adverse effects
Extravasation of Diagnostic and Therapeutic Materials - drug therapy
Fatal Outcome
Humans
Male
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Summary:DMSO is a dipolar, aprotic, hygroscopic solvent for which a large number of pharmacologic properties have been claimed. Topical DMSO is considered an effective and safe antidote to be used with topical cooling after extravasations of vesicant drugs. A case of toxicity after its use as an antidote is described. Furthermore, the increasing importance of DMSO pharmacology, as its use in haematologic patients is spreading, is reviewed.
ISSN:0928-1231
2210-7703
2210-7711
DOI:10.1023/A:1020528203296