Analysis of the initial burst of drug release coupled with polymer surface degradation

Local pH effect on the release of a model pH-inert hydrophobic drug coupled with polymer degradation is described at the induction phase of biodegradable polymer erosion for better understanding the nature of initial burst of a drug. Using a novel approach with time-of-flight secondary ion mass spec...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutical research 2003-02, Vol.20 (2), p.149-152
Main Authors: LEE, Joo-Woon, GARDELLA, Joseph A, HICKS, Wesley JR, HARD, Robert, BRIGHT, Frank V
Format: Article
Language:English
Subjects:
Biological and medical sciences
Drug delivery systems
Electron microscopes
General pharmacology
Mass spectrometry
Medical sciences
Molecular weight
Morphology
Pharmaceutical Preparations - analysis
Pharmaceutical Preparations - metabolism
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polymer blends
Polymers - analysis
Polymers - pharmacokinetics
Scientific imaging
Surface Properties
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Local pH effect on the release of a model pH-inert hydrophobic drug coupled with polymer degradation is described at the induction phase of biodegradable polymer erosion for better understanding the nature of initial burst of a drug. Using a novel approach with time-of-flight secondary ion mass spectrometry. both surface concentration of Ph3N and degradation kinetics of PLLA are simultaneously and independently determined from a model Ph3N/PLLA (20:80 wt%) blend matrix (t approximately 0.4 microm on 1.0 cm2). In vitro hydrolysis of the model blend matrix is investigated for short-term periods (
ISSN:0724-8741
1573-904X
DOI:10.1023/A:1022202632685